Concepedia

Essential Gene Knockout

Essential Gene Knockout is a genetic intervention strategy in which a gene indispensable for organismal viability or cellular function is selectively inactivated to elucidate its biological role and phenotypic consequences.

114

Publications

9K

Citations

735

Authors

238

Institutions

Publications per year

2017–2026

33

Parents

Publications

114

Site-specific selfish genes as tools for the control and genetic engineering of natural populations

Austin Burt · Proceedings of the Royal Society B Biological Sciences · 2003 · 758 citations · Full text

, , +15

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Traver Hart, Amy H.Y. Tong, Katie Chan et al. · G3 Genes Genomes Genetics · 2017 · 681 citations · Full text

, , +16

Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

Sabine Heber, Jochen Herms, Vladan Gajic et al. · Journal of Neuroscience · 2000 · 487 citations · Full text

, , +17

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Zhijian Li, Franco J. Vizeacoumar, Sondra Bahr et al. · Nature Biotechnology · 2011 · 441 citations · Full text

, , +11

BAGEL: a computational framework for identifying essential genes from pooled library screens

Traver Hart, Jason Moffat · BMC Bioinformatics · 2016 · 325 citations · Full text

, , +17

1–5 of 114

Authors

735

  1. CB
    Charles Boone

    University of Toronto, Canada

    5 publications · 1.3K citations

    5

    h-index

  2. BA
    Brenda Andrews

    University of Toronto, Canada

    5 publications · 1.3K citations

    5

    h-index

  3. CL
    Chad L. Myers

    University of Minnesota, United States

    5 publications · 1.3K citations

    5

    h-index

  4. ZL
    Zhijian Li

    University of Toronto, Canada

    3 publications · 533 citations

    3

    h-index

  5. MC
    Michael Costanzo

    University of Toronto, Canada

    3 publications · 1.1K citations

    3

    h-index

1–5 of 735

Institutions

238

  1. University of Toronto

    Toronto, Canada

    6 h-index

    89 publications

    28.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    18 publications

    919 citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    5 h-index

    11 publications

    2K citations

  4. University of Minnesota

    Minneapolis, United States

    5 h-index

    11 publications

    3.6K citations

  5. Lunenfeld-Tanenbaum Research Institute

    Toronto, Canada

    4 h-index

    11 publications

    3.1K citations

  6. Mount Sinai Hospital

    Toronto, Canada

    3 h-index

    7 publications

    2.8K citations

  7. University of Florida

    Gainesville, United States

    3 h-index

    16 publications

    630 citations

  8. Keio University

    Tokyo, Japan

    3 h-index

    6 publications

    900 citations

1–8 of 238

Venues

  1. PLoS ONE

    7 publications · 332 citations

    7

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 735 citations

    5

    h-index

  3. Journal of Bacteriology

    JB · 5 publications · 406 citations

    5

    h-index

  4. Molecular and Cellular Biology

    MCB · 4 publications · 426 citations

    4

    h-index

  5. Nucleic Acids Research

    3 publications · 327 citations

    3

    h-index

1–5