Concepedia

Essential Gene Interactions

Essential Gene Interactions is a theoretical construct in functional genomics that identifies pairs or sets of genes whose combined inactivation leads to cell death, whereas the inactivation of either gene alone is non-lethal, thereby revealing synthetic lethal relationships critical for understanding genetic robustness and identifying therapeutic targets.

57

Publications

5K

Citations

401

Authors

147

Institutions

Publications per year

2017–2026

13

Parents

Publications

57

A global genetic interaction network maps a wiring diagram of cellular function

Michael Costanzo, Benjamin VanderSluis, Elizabeth N. Koch et al. · Science · 2016 · 1.4K citations · Full text

, , +15

The synthetic genetic interaction spectrum of essential genes

Armaity P. Davierwala, Jennifer Haynes, Zhijian Li et al. · Nature Genetics · 2005 · 225 citations

, , +14

A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue

Rebecca A. Green, Huey-Ling Kao, Anjon Audhya et al. · Cell · 2011 · 224 citations · Full text

, , +10

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

Scott J. Dixon, Yaroslav Fedyshyn, Judice L.Y. Koh et al. · Proceedings of the National Academy of Sciences · 2008 · 217 citations · Full text

, , +17

Rapid evolutionary turnover underlies conserved lncRNA–genome interactions

Jeffrey J. Quinn, Qiangfeng Cliff Zhang, Plamen Georgiev et al. · Genes & Development · 2016 · 207 citations · Full text

, , +15

1–5 of 57

Authors

401

  1. BA
    Brenda Andrews

    University of Toronto, Canada

    4 publications · 1.9K citations

    4

    h-index

  2. CB
    Charles Boone

    University of Toronto, Canada

    4 publications · 1.9K citations

    4

    h-index

  3. PH
    Philip Hieter

    Johns Hopkins University, United States

    3 publications · 250 citations

    3

    h-index

  4. IB
    Irene Barrett

    University of British Columbia, Canada

    2 publications · 213 citations

    2

    h-index

  5. MC
    Michael Costanzo

    University of Toronto, Canada

    2 publications · 1.4K citations

    2

    h-index

1–5 of 401

Institutions

147

  1. University of Wisconsin–Madison

    Madison, United States

    5 h-index

    24 publications

    2.5K citations

  2. University of Toronto

    Toronto, Canada

    4 h-index

    56 publications

    45.8K citations

  3. Harvard University

    Cambridge, United States

    4 h-index

    10 publications

    647 citations

  4. University of California, Davis

    Davis, United States

    3 h-index

    4 publications

    516 citations

  5. Imperial College London

    London, United Kingdom

    3 h-index

    6 publications

    1.6K citations

  6. Canada's Michael Smith Genome Sciences Centre

    Vancouver, Canada

    3 h-index

    16 publications

    1.3K citations

  7. University of British Columbia

    Vancouver, Canada

    3 h-index

    18 publications

    1.5K citations

  8. Princeton University

    Princeton, United States

    2 h-index

    3 publications

    2.8K citations

1–8 of 147

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 594 citations

    5

    h-index

  2. Genome biology

    3 publications · 139 citations

    3

    h-index

  3. Genetics

    3 publications · 156 citations

    3

    h-index

  4. PLoS ONE

    2 publications · 99 citations

    3

    h-index

  5. Nature Communications

    2 publications · 189 citations

    2

    h-index

1–5