Concepedia

Epitope Scaffolding

Epitope Scaffolding is a protein engineering method in which a structurally defined epitope is transplanted onto a heterologous protein scaffold to stabilize its conformation and enable targeted immune recognition.

42

Publications

2.2K

Citations

315

Authors

95

Institutions

Publications per year

2017–2026

10

Variants

Epitope Grafting

Parents

Publications

42

Elicitation of structure-specific antibodies by epitope scaffolds

Gilad Ofek, F. Javier Guenaga, William R. Schief et al. · Proceedings of the National Academy of Sciences · 2010 · 282 citations · Full text

, , +17

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

Bruno E. Correia, Yih‐En Andrew Ban, Margaret A. Holmes et al. · Structure · 2010 · 224 citations · Full text

, , +17

Structural insights and biomedical potential of IgNAR scaffolds from sharks

Stefan Zielonka, Martin Empting, Julius Grzeschik et al. · mAbs · 2014 · 143 citations · Full text

, , +17

Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope

Mihai L. Azoitei, Yih‐En Andrew Ban, Jean‐Philippe Julien et al. · Journal of Molecular Biology · 2011 · 103 citations · Full text

, , +17

Monobodies: Antibody Mimics Based on the Scaffold of the Fibronectin Type III Domain

Akiko Koide, Shohei Koide · Humana Press eBooks · 2006 · 96 citations

, , +17

1–5 of 42

Authors

315

  1. WR
    William R. Schief

    Scripps Research Institute, United States

    5 publications · 713 citations

    5

    h-index

  2. RM
    Rob M. J. Liskamp

    Utrecht University, Netherlands

    4 publications · 92 citations

    4

    h-index

  3. DB
    David Baker

    University of Washington, United States

    4 publications · 691 citations

    4

    h-index

  4. RT
    Richard T. Wyatt

    National Institutes of Health, United States

    3 publications · 386 citations

    3

    h-index

  5. PD
    Peter D. Kwong

    National Institutes of Health, United States

    3 publications · 434 citations

    3

    h-index

1–5 of 315

Institutions

95

  1. University of Washington

    Seattle, United States

    5 h-index

    25 publications

    3.3K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    16 publications

    503 citations

  3. Stanford University

    Stanford, United States

    4 h-index

    10 publications

    360 citations

  4. Utrecht University

    Utrecht, The Netherlands

    4 h-index

    16 publications

    353 citations

  5. International AIDS Vaccine Initiative

    New York, United States

    3 h-index

    7 publications

    357 citations

  6. Heidelberg University

    Heidelberg, Germany

    3 h-index

    13 publications

    299 citations

  7. Ragon Institute of MGH, MIT and Harvard

    Cambridge, United States

    3 h-index

    15 publications

    494 citations

  8. Duke University

    Durham, United States

    3 h-index

    36 publications

    971 citations

1–8 of 95

Venues

  1. Scientific Reports

    3 publications · 153 citations

    3

    h-index

  2. PLoS ONE

    3 publications · 128 citations

    3

    h-index

  3. ChemBioChem

    2 publications · 118 citations

    2

    h-index

  4. Chemical Communications

    ChemComm · 2 publications · 47 citations

    2

    h-index

  5. Nature Communications

    2 publications · 54 citations

    2

    h-index

1–5