Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Trude Helen Flo, Kelly D. Smith, Shintaro Sato, +5

Nature

InflammationHost ResponseBacterial InfectionPathogenesisImmunology +8

The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition

David H. Goetz, Margaret A. Holmes, Niels Borregaard, +3

Molecular Cell

InflammationNeutrophil Lipocalin NgalBiochemistryGranulocyteIron Metabolism +11

Proof of principle for epitope-focused vaccine design

Bruno E. Correia, John T. Bates, Rebecca J. Loomis, +24

Nature

VaccinationEpitope-focused Vaccine DesignCross-protectionVaccine TargetImmunology +4

HLA-E Allelic Variants

Roland K. Strong, Margaret A. Holmes, Pingwei Li, +3

Journal of Biological Chemistry

Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration

Margaret A. Holmes, Wendy Paulsene, Jide Xu, +2

Structure

Medical MicrobiologyBinds CarboxymycobactinsLcn 2MetalloproteinPathogenesis +8

Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

Bruno E. Correia, Yih-En Andrew Ban, Margaret A. Holmes, +15

Structure

VaccinationMedicineVaccine TargetImmunologyEpitope-scaffolds Allows Induction +9

Structures of deoxy and oxy hemerythrin at 2.0 Å resolution

Margaret A. Holmes, I. Le Trong, S. Turley, +2

Journal of Molecular Biology

Inorganic ChemistryBiochemistryHeme DegradationRedox ChemistryOxy Hemerythrin +4

Crystal structure of a γδ T-cell receptor specific for the human MHC class I homolog MICA

Bin Xu, J.C. Pizarro, Margaret A. Holmes, +4

Proceedings of the National Academy of Sciences

Crystal StructureAdaptive Immune SystemImmunologyImmune RegulationMolecular Biology +17

“Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28

Philip Tan, David A. Mitchell, Timothy N. Buss, +3

The Journal of Immunology

Structures of met and azidomet hemerythrin at 1·66 Å resolution

Margaret A. Holmes, Ronald E. Stenkamp

Journal of Molecular Biology

Inorganic ChemistryBiochemistryNatural SciencesStructure ElucidationChemistry +2