Concepedia

Epigenetic Initiation

Epigenetic Initiation is a biological mechanism within the broader category of cancer initiation that involves heritable changes in gene expression and cellular phenotype without alterations to the underlying DNA sequence, distinguished by the dysregulation of epigenetic marks such as DNA methylation, histone modification, and non-coding RNA activity.

30

Publications

1.8K

Citations

270

Authors

100

Institutions

Publications per year

2017–2026

9

Parents

Publications

30

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

Mark M. Pomerantz, Xintao Qiu, Yanyun Zhu et al. · Nature Genetics · 2020 · 289 citations · Full text

, , +16

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Zachary D. Smith, Jiantao Shi, Hongcang Gu et al. · Nature · 2017 · 213 citations · Full text

, , +16

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

Emma K. Baker, Ricky W. Johnstone, John Zalcberg et al. · Oncogene · 2005 · 193 citations

, , +12

Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis

Phillip M. Cheng, Christoph Schmütte, K. F. Cofer et al. · British Journal of Cancer · 1997 · 82 citations · Full text

, , +14

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

Daniel Nettersheim, Sina Jostes, Rakesh Sharma et al. · PLoS Genetics · 2015 · 80 citations · Full text

, , +15

1–5 of 30

Authors

270

  1. KH
    Kelly H. Clifton

    University of Wisconsin–Madison, United States

    2 publications · 74 citations

    2

    h-index

  2. JF
    James F. Beck

    Jena University Hospital, Germany

    1 publications · 38 citations

    1

    h-index

  3. CG
    Claudia Giambartolomei

    University of California, Los Angeles, United States

    1 publications · 289 citations

    1

    h-index

  4. FB
    Filip Bednar

    University of Michigan, United States

    1 publications · 33 citations

    1

    h-index

  5. PM
    Phillip M. Cheng

    Keck Hospital of USC, United States

    1 publications · 82 citations

    1

    h-index

1–5 of 270

Institutions

100

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    18 publications

    1.2K citations

  2. University of Wisconsin–Madison

    Madison, United States

    3 h-index

    15 publications

    625 citations

  3. Harvard University

    Cambridge, United States

    3 h-index

    28 publications

    7.3K citations

  4. Broad Institute

    Cambridge, United States

    3 h-index

    12 publications

    2.4K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    25 publications

    7.1K citations

  6. Fred Hutch Cancer Center

    Seattle, United States

    2 h-index

    2 publications

    310 citations

  7. University of Southern California

    Los Angeles, United States

    2 h-index

    5 publications

    372 citations

  8. USC Norris Comprehensive Cancer Center

    Los Angeles, United States

    2 h-index

    4 publications

    290 citations

1–8 of 100

Venues

  1. Nature

    3 publications · 327 citations

    3

    h-index

  2. Carcinogenesis

    2 publications · 69 citations

    2

    h-index

  3. British Journal of Cancer

    BJC · 2 publications · 121 citations

    2

    h-index

  4. Oncogene

    1 publications · 193 citations

    1

    h-index

  5. Haematologica

    1 publications · 21 citations

    1

    h-index

1–5