The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours<i>in vitro</i>and<i>in vivo</i>

Sina Jostes, Daniel Nettersheim, Martin Fellermeyer, +7

Journal of Cellular and Molecular Medicine

Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile

Simon Schneider, Melanie Balbach, Jan F. Jikeli, +9

Scientific Reports

N6‐Methyladenosine detected in <scp>RNA</scp> of testicular germ cell tumors is controlled by <scp>METTL</scp>3, <scp>ALKBH</scp>5, <scp>YTHDC</scp>1/F1/F2, and <scp>HNRNPC</scp> as writers, erasers, and readers

Daniel Nettersheim, Daniel R. Berger, Sina Jostes, +3

Andrology

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

Daniel Nettersheim, Sina Jostes, Rakesh Sharma, +7

PLoS Genetics

Cancer ResearchSeminomas Initiates AcquisitionLineage PlasticityDevelopmental BiologyEmbryonal Carcinoma +13

The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

Daniel Nettersheim, I Arndt, Rakesh Sharma, +6

British Journal of Cancer

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

Daniel Nettersheim, Sina Jostes, Martin Fabry, +5

Oncotarget

SOX2 is essential for <i>in vivo</i> reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate

Daniel Nettersheim, Alena Heimsoeth, Sina Jostes, +4

Oncotarget

Cancer BiologyTumor BiologyTissue DevelopmentCell RegulationGerm Cell Development +14

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate

Sina Jostes, Martin Fellermeyer, Lena Arévalo, +4

International Journal of Cancer

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

Margaretha A. Skowron, Teresa K. Becker, Lukas Kurz, +17

Molecular Oncology

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

Daniel Nettersheim, Saskia Vadder, Sina Jostes, +2

Cancers