Concepedia

Epigenetic Immune Reprogramming

Epigenetic Immune Reprogramming is a developmental immunotoxicity mechanism whereby environmental exposures induce stable alterations in immune cell function through heritable, non-sequence-based modifications to gene expression, such as DNA methylation, histone modification, or non-coding RNA regulation, without changing the underlying genetic code.

77

Publications

9.3K

Citations

835

Authors

269

Institutions

Publications per year

2017–2026

53

Parents

Publications

77

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers et al. · Proceedings of the National Academy of Sciences · 2012 · 1.7K citations · Full text

, , +17

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng, Ilona Kryczek, Nisha Nagarsheth et al. · Nature · 2015 · 1.2K citations · Full text

, , +17

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Rob J.W. Arts, Boris Novakovic, Rob ter Horst et al. · Cell Metabolism · 2016 · 858 citations · Full text

, , +10

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers et al. · Journal of Innate Immunity · 2013 · 627 citations · Full text

, , +17

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Daisuke Ennishi, Katsuyoshi Takata, Wendy Béguelin et al. · Cancer Discovery · 2019 · 316 citations

, , +17

1–5 of 77

Authors

835

  1. MG
    Mihai G. Netea

    Radboud University Nijmegen, Netherlands

    11 publications · 4K citations

    11

    h-index

  2. LA
    Leo A. B. Joosten

    Radboud University Nijmegen, Netherlands

    8 publications · 3.8K citations

    8

    h-index

  3. JV
    J.W.M. van der Meer

    Radboud University Nijmegen, Netherlands

    5 publications · 3.5K citations

    5

    h-index

  4. RV
    Reinout van Crevel

    Radboud University Nijmegen, Netherlands

    4 publications · 3.4K citations

    4

    h-index

  5. RJ
    Ramnik J. Xavier

    Massachusetts General Hospital, United States

    4 publications · 3.4K citations

    4

    h-index

1–5 of 835

Institutions

269

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    11 h-index

    105 publications

    39.2K citations

  2. Radboud University Medical Center

    Nijmegen, The Netherlands

    11 h-index

    89 publications

    30K citations

  3. Harvard University

    Cambridge, United States

    7 h-index

    23 publications

    5.8K citations

  4. Massachusetts General Hospital

    Boston, United States

    5 h-index

    18 publications

    4.9K citations

  5. Broad Institute

    Cambridge, United States

    5 h-index

    9 publications

    4.6K citations

  6. Cornell University

    Ithaca, United States

    5 h-index

    49 publications

    3.7K citations

  7. Radboud Institute for Molecular Life Sciences

    Nijmegen, The Netherlands

    5 h-index

    21 publications

    8.1K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    4 h-index

    7 publications

    4K citations

1–8 of 269

Venues

  1. Frontiers in Immunology

    7 publications · 334 citations

    7

    h-index

  2. Nature Immunology

    3 publications · 260 citations

    3

    h-index

  3. Nature Communications

    3 publications · 150 citations

    3

    h-index

  4. The Journal of Immunology

    JI · 3 publications · 64 citations

    3

    h-index

  5. Cell Metabolism

    3 publications · 1.1K citations

    3

    h-index

1–5