Concepedia

Enzyme-transporter Interactions

Enzyme-Transporter Interactions is a pharmacokinetic mechanism characterized by the coordinated interplay between hepatic metabolizing enzymes and membrane transport proteins that collectively modulate the uptake, metabolism, and biliary excretion of drugs within hepatocytes.

113

Publications

6K

Citations

524

Authors

168

Institutions

Publications per year

2017–2026

21

Parents

Publications

113

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

Stephan R. Vavricka, Jessica van Montfoort, Huy Riêm Ha et al. · Hepatology · 2002 · 372 citations · Full text

, , +17

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

Maria Karlgren, Anna Vildhede, Ulf Norinder et al. · Journal of Medicinal Chemistry · 2012 · 365 citations · Full text

, , +14

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 340 citations · Full text

, , +17

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

Nicola F. Smith, Milin Acharya, Neil Desai et al. · Cancer Biology & Therapy · 2005 · 236 citations · Full text

, , +17

Substituted methcathinones differ in transporter and receptor interactions

Amy J. Eshleman, Katherine M. Wolfrum, Meagan G. Hatfield et al. · Biochemical Pharmacology · 2013 · 231 citations

, , +12

1–5 of 113

Authors

524

  1. MV
    Manthena V. S. Varma

    Pfizer (United States), United States

    4 publications · 213 citations

    4

    h-index

  2. YB
    Yi‐An Bi

    Pfizer (United States), United States

    4 publications · 182 citations

    4

    h-index

  3. EK
    Emi Kimoto

    Pfizer (United States), United States

    3 publications · 483 citations

    3

    h-index

  4. YK
    Yukio Kato

    Kanazawa University, Japan

    3 publications · 133 citations

    3

    h-index

  5. JL
    Jian Lin

    Pfizer (United States), United States

    3 publications · 174 citations

    3

    h-index

1–5 of 524

Institutions

168

  1. Pfizer (United States)

    New York, United States

    8 h-index

    36 publications

    2.4K citations

  2. Kanazawa University

    Kanazawa, Japan

    5 h-index

    21 publications

    746 citations

  3. University of Toronto

    Toronto, Canada

    3 h-index

    13 publications

    372 citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    6 publications

    392 citations

  5. University of Groningen

    Groningen, The Netherlands

    3 h-index

    12 publications

    477 citations

  6. Instituto Português de Oncologia Francisco Gentil

    Lisbon, Portugal

    3 h-index

    6 publications

    76 citations

  7. University of Florida

    Gainesville, United States

    3 h-index

    9 publications

    531 citations

  8. University of Houston

    Houston, United States

    2 h-index

    5 publications

    137 citations

1–8 of 168

Venues

  1. Drug Metabolism and Disposition

    15 publications · 493 citations

    14

    h-index

  2. 8

    h-index

  3. Journal of Biological Chemistry

    JBC · 4 publications · 198 citations

    4

    h-index

  4. Biochemical Pharmacology

    4 publications · 378 citations

    4

    h-index

  5. Life Sciences

    3 publications · 89 citations

    3

    h-index

1–5