Concepedia

Enzyme Evolution Modeling

Enzyme Evolution Modeling is a computational framework that simulates the natural evolutionary processes of enzymes by integrating sequence, structure, and functional constraints to predict adaptive mutations and guide the rational design of improved biocatalysts.

71

Publications

4.4K

Citations

289

Authors

138

Institutions

Publications per year

2017–2026

15

Parents

Publications

71

Chaperonin overexpression promotes genetic variation and enzyme evolution

Nobuhiko Tokuriki, Dan S. Tawfik · Nature · 2009 · 369 citations

, , +16

Directed Evolution of Enantioselective Enzymes: Iterative Cycles of CASTing for Probing Protein‐Sequence Space

Manfred T. Reetz, Marco Bocola · Angewandte Chemie International Edition · 2006 · 362 citations

, , +17

The role of protein dynamics in the evolution of new enzyme function

E.C. Campbell, Miriam Kaltenbach, G.J. Correy et al. · Nature Chemical Biology · 2016 · 343 citations

, , +14

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

Dong‐Sun Lee, Pierre Nioche, Mats Hámberg et al. · Nature · 2008 · 292 citations

, , +16

Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry

Jean‐Benoît Lalanne, James Taggart, Monica S. Guo et al. · Cell · 2018 · 191 citations · Full text

, , +14

1–5 of 71

Authors

289

  1. MB
    Marco Bocola

    RWTH Aachen University, Germany

    4 publications · 517 citations

    4

    h-index

  2. NT
    Nobuhiko Tokuriki

    Canada's Michael Smith Genome Sciences Centre, Canada

    3 publications · 856 citations

    3

    h-index

  3. DS
    Dan S. Tawfik

    Weizmann Institute of Science, Israel

    3 publications · 706 citations

    3

    h-index

  4. CJ
    Colin J. Jackson

    Australian National University, Australia

    3 publications · 593 citations

    3

    h-index

  5. IM
    Ichiro Matsumura

    Emory University, United States

    2 publications · 73 citations

    2

    h-index

1–5 of 289

Institutions

138

  1. Max-Planck-Institut für Kohlenforschung

    Mülheim, Germany

    4 h-index

    12 publications

    1.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    523 citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    10 publications

    2.1K citations

  4. Novo Nordisk Foundation

    Copenhagen, Denmark

    2 h-index

    2 publications

    42 citations

  5. Stanford University

    Stanford, United States

    2 h-index

    3 publications

    88 citations

  6. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    4 publications

    631 citations

  7. Canada's Michael Smith Genome Sciences Centre

    Vancouver, Canada

    2 h-index

    4 publications

    974 citations

  8. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    4 publications

    720 citations

1–8 of 138

Venues

  1. Journal of Molecular Biology

    JMB · 6 publications · 467 citations

    6

    h-index

  2. Journal of Theoretical Biology

    4 publications · 50 citations

    4

    h-index

  3. Journal of Molecular Evolution

    4 publications · 242 citations

    4

    h-index

  4. Journal of the American Chemical Society

    JACS · 3 publications · 96 citations

    3

    h-index

  5. Angewandte Chemie

    3 publications · 150 citations

    3

    h-index

1–5