Concepedia

Enhancer Context Dependence

Enhancer Context Dependence is a genomic regulatory principle denoting the phenomenon whereby the activity and functional output of an enhancer element are contingent upon the specific cellular, spatial, temporal, or epigenomic environment in which it operates, rather than being intrinsically fixed or universally active across contexts.

10

Publications

618

Citations

79

Authors

30

Institutions

Publications per year

2017–2026

6

Parents

Publications

10

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

Hannah K. Long, Marco Osterwalder, Ian Welsh et al. · Cell stem cell · 2020 · 178 citations · Full text

, , +17

Differential cofactor dependencies define distinct types of human enhancers

Christoph Neumayr, Vanja Haberle, Leonid Serebreni et al. · Nature · 2022 · 111 citations · Full text

, , +13

Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific

Jo Taylor, Tess Levy, Eun Ran Suh et al. · Nucleic Acids Research · 1997 · 72 citations · Full text

, , +17

Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus

Ran Brosh, Camila Coelho, André M. Ribeiro-dos-Santos et al. · Molecular Cell · 2023 · 68 citations · Full text

, , +16

An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP

Marc Fiedler, Michael Graeb, Juliusz Mieszczanek et al. · eLife · 2015 · 65 citations · Full text

, , +17

1–5 of 10

Authors

79

  1. AS
    Alexander Stark

    Research Institute of Molecular Pathology, Austria

    2 publications · 135 citations

    2

    h-index

  2. JF
    John F. Fullard

    Icahn School of Medicine at Mount Sinai, United States

    1 publications · 25 citations

    1

    h-index

  3. MK
    Mervenaz Koska

    California Institute for Regenerative Medicine, United States

    1 publications · 178 citations

    1

    h-index

  4. DD
    Denis Duboule

    University of Geneva, Switzerland

    1 publications · 23 citations

    1

    h-index

  5. DR
    Douglas R. Higgs

    John Radcliffe Hospital, United Kingdom

    1 publications · 178 citations

    1

    h-index

1–5 of 79

Institutions

30

  1. Research Institute of Molecular Pathology

    Vienna, Austria

    2 h-index

    15 publications

    1.4K citations

  2. Medical University of Vienna

    Vienna, Austria

    2 h-index

    7 publications

    516 citations

  3. Vienna Biocenter

    Vienna, Austria

    2 h-index

    9 publications

    738 citations

  4. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    1 h-index

    3 publications

    69 citations

  5. Whitehead Institute for Biomedical Research

    Cambridge, United States

    1 h-index

    3 publications

    333 citations

  6. MRC Human Immunology Unit

    Oxford, United Kingdom

    1 h-index

    1 publications

    178 citations

  7. University of Crete

    Rethymno, Greece

    1 h-index

    3 publications

    75 citations

  8. The Francis Crick Institute

    London, United Kingdom

    1 h-index

    1 publications

    178 citations

1–8 of 30

Venues

  1. Genome Research

    GR · 1 publications · 24 citations

    1

    h-index

  2. Nucleic Acids Research

    1 publications · 72 citations

    1

    h-index

  3. Genome Biology and Evolution

    GBE · 1 publications · 21 citations

    1

    h-index

  4. Cell stem cell

    1 publications · 178 citations

    1

    h-index

  5. Nature Communications

    1 publications · 23 citations

    1

    h-index

1–5