Concepedia

Engineered Proteases

Engineered Proteases is a class of modified enzymatic proteins derived from natural proteases through targeted molecular alterations to enhance or introduce specific catalytic properties, substrate specificities, or environmental stability for precise applications in post-translational modification engineering.

224

Publications

11.4K

Citations

1.1K

Authors

324

Institutions

Publications per year

2017–2026

56

Parents

Publications

224

Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.

Kun Chen, Frances H. Arnold · Proceedings of the National Academy of Sciences · 1993 · 541 citations

, , +16

Constructing Proteins by Dovetailing Unprotected Synthetic Peptides: Backbone-Engineered HIV Protease

Martina Schnölzer, Stephen B. H. Kent · Science · 1992 · 362 citations

, , +17

Complete mutagenesis of the HIV-1 protease

Daniel D. Loeb, Ronald Swanstrom, Lorraine Everitt et al. · Nature · 1989 · 335 citations

, , +14

Improved solubility of TEV protease by directed evolution

Susanne van den Berg, Per‐Åke Löfdahl, Torleif Härd et al. · Journal of Biotechnology · 2005 · 322 citations

, , +14

Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution

Lars Abrahmsén, Jeffrey Tom, John P. Burnier et al. · Biochemistry · 1991 · 247 citations

, , +15

1–5 of 224

Authors

1.1K

  1. GG
    George Georgiou

    The University of Texas at Austin, United States

    6 publications · 421 citations

    6

    h-index

  2. BL
    Brent L. Iverson

    The University of Texas at Austin, United States

    6 publications · 421 citations

    6

    h-index

  3. JA
    James A. Wells

    University of California, San Francisco, United States

    5 publications · 673 citations

    5

    h-index

  4. CS
    Charles S. Craik

    University of California, San Francisco, United States

    4 publications · 277 citations

    4

    h-index

  5. NV
    Navin Varadarajan

    University of Houston, United States

    3 publications · 218 citations

    3

    h-index

1–5 of 1.1K

Institutions

324

  1. University of California, San Francisco

    San Francisco, United States

    10 h-index

    31 publications

    2.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    15 publications

    1K citations

  3. Scripps Research Institute

    San Diego, United States

    6 h-index

    13 publications

    1.2K citations

  4. The University of Texas at Austin

    Austin, United States

    6 h-index

    31 publications

    2.2K citations

  5. University of Groningen

    Groningen, The Netherlands

    5 h-index

    18 publications

    661 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    8 publications

    353 citations

  7. The University of Queensland

    Brisbane, Australia

    5 h-index

    21 publications

    1.4K citations

  8. The University of Tokyo

    Tokyo, Japan

    5 h-index

    16 publications

    831 citations

1–8 of 324

Venues

  1. Biochemistry

    14 publications · 809 citations

    13

    h-index

  2. Journal of Biological Chemistry

    JBC · 10 publications · 604 citations

    10

    h-index

  3. Applied Microbiology and Biotechnology

    7 publications · 290 citations

    7

    h-index

  4. 7

    h-index

  5. Journal of the American Chemical Society

    JACS · 7 publications · 296 citations

    7

    h-index

1–5