Concepedia

Engineered Kinases

Engineered Kinases is a synthetic biological tool comprising modified kinase enzymes designed through rational design or directed evolution to exhibit altered substrate specificity, activity, or regulatory properties for targeted manipulation of cellular signaling pathways in post-translational modification engineering.

99

Publications

6K

Citations

494

Authors

160

Institutions

Publications per year

2017–2026

16

Parents

Publications

99

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

Kavita Shah, Yi Liu, Carl Deirmengian et al. · Proceedings of the National Academy of Sciences · 1997 · 418 citations

, , +12

A semisynthetic epitope for kinase substrates

Jasmina J. Allen, Manqing Li, Craig S. Brinkworth et al. · Nature Methods · 2007 · 333 citations

, , +13

Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light

Michael Grusch, Karin Schelch, Robert Riedler et al. · The EMBO Journal · 2014 · 266 citations · Full text

, , +14

Engineered allosteric activation of kinases in living cells

Andrei V. Karginov, Feng Ding, Pradeep Kota et al. · Nature Biotechnology · 2010 · 208 citations · Full text

, , +14

Optical control of cell signaling by single-chain photoswitchable kinases

Linlin Z. Fan, Pengpeng Li, Kang Shen et al. · Science · 2017 · 202 citations · Full text

, , +8

1–5 of 99

Authors

494

  1. KM
    Kevan M. Shokat

    University of California, San Francisco, United States

    14 publications · 1.4K citations

    14

    h-index

  2. KS
    Kavita Shah

    Purdue University West Lafayette, United States

    9 publications · 926 citations

    9

    h-index

  3. AV
    Andrei V. Karginov

    University of Illinois Chicago, United States

    4 publications · 336 citations

    4

    h-index

  4. KM
    Klaus M. Hahn

    University of North Carolina at Chapel Hill, United States

    4 publications · 336 citations

    4

    h-index

  5. KM
    Kevan M. Shokat

    University of California, San Francisco, United States

    4 publications · 279 citations

    4

    h-index

1–5 of 494

Institutions

160

  1. University of California, San Francisco

    San Francisco, United States

    17 h-index

    60 publications

    5.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    29 publications

    3.1K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    25 publications

    3K citations

  4. University of Washington

    Seattle, United States

    6 h-index

    24 publications

    1.1K citations

  5. Princeton University

    Princeton, United States

    6 h-index

    17 publications

    2.9K citations

  6. University of California, Berkeley

    Berkeley, United States

    6 h-index

    11 publications

    623 citations

  7. Harvard University

    Cambridge, United States

    5 h-index

    22 publications

    2.6K citations

  8. University of California San Diego

    San Diego, United States

    5 h-index

    17 publications

    1.6K citations

1–8 of 160

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 905 citations

    13

    h-index

  2. Biochemistry

    7 publications · 210 citations

    7

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 756 citations

    5

    h-index

  4. Journal of the American Chemical Society

    JACS · 5 publications · 398 citations

    5

    h-index

  5. ACS Chemical Biology

    3 publications · 90 citations

    3

    h-index

1–5