Concepedia

Drug Target Polymorphisms

Drug Target Polymorphisms is a genetic variation in the DNA sequence of a gene encoding a protein or biomolecule that directly interacts with a pharmacological agent, thereby altering the drug's binding affinity, efficacy, or therapeutic response.

72

Publications

4.2K

Citations

432

Authors

190

Institutions

Publications per year

2017–2026

27

Variants

Drug Target Polymorphism

Parents

Publications

72

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Ultan McDermott, Sreenath V. Sharma, Lori Dowell et al. · Proceedings of the National Academy of Sciences · 2007 · 358 citations · Full text

, , +17

Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir

Yanmei Hu, Eric M. Lewandowski, Haozhou Tan et al. · ACS Central Science · 2023 · 306 citations · Full text

, , +17

UGT1A7 and UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with Capecitabine/Irinotecan

Leslie E. Carlini, Neal J. Meropol, John L. Bever et al. · Clinical Cancer Research · 2005 · 261 citations · Full text

, , +17

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Hai Fang, Hans Wolf, Bogdan Knezevic et al. · Nature Genetics · 2019 · 232 citations · Full text

, , +11

Selection of Antibiotic‐Resistant Bacterial Mutants: Allelic Diversity among Fluoroquinolone‐Resistant Mutations

Jianfeng Zhou, Yuzhi Dong, Xilin Zhao et al. · The Journal of Infectious Diseases · 2000 · 147 citations · Full text

, , +17

1–5 of 72

Authors

432

  1. TR
    Tom R. Gaunt

    University of Bristol, United Kingdom

    4 publications · 196 citations

    4

    h-index

  2. IC
    I. Chopra

    University of Leeds, United Kingdom

    3 publications · 146 citations

    3

    h-index

  3. AJ
    Alex J. O’Neill

    University of Leeds, United Kingdom

    3 publications · 146 citations

    3

    h-index

  4. GD
    George Davey Smith

    University of Bristol, United Kingdom

    3 publications · 166 citations

    3

    h-index

  5. XD
    Xufang Deng

    Loyola University Chicago, United States

    2 publications · 399 citations

    2

    h-index

1–5 of 432

Institutions

190

  1. University of Bristol

    Bristol, United Kingdom

    4 h-index

    25 publications

    1.3K citations

  2. Amgen (United States)

    Thousand Oaks, United States

    4 h-index

    18 publications

    932 citations

  3. University of Michigan

    Ann Arbor, United States

    4 h-index

    7 publications

    428 citations

  4. Massachusetts General Hospital

    Boston, United States

    3 h-index

    25 publications

    7.4K citations

  5. Université Paris Cité

    Paris, France

    3 h-index

    6 publications

    328 citations

  6. University of Leeds

    Leeds, United Kingdom

    3 h-index

    11 publications

    518 citations

  7. NIHR Bristol Biomedical Research Centre

    Bristol, United Kingdom

    3 h-index

    8 publications

    338 citations

  8. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

    Madrid, Spain

    2 h-index

    3 publications

    39 citations

1–8 of 190

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 3 publications · 131 citations

    3

    h-index

  2. PLoS ONE

    3 publications · 240 citations

    3

    h-index

  3. Pharmacogenomics

    2 publications · 95 citations

    2

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 113 citations

    2

    h-index

  5. Scientific Reports

    2 publications · 144 citations

    2

    h-index

1–5