Concepedia

Domain Pairing

Domain Pairing is a structural modeling framework in immunology that specifies the spatial and functional association between variable domains of heavy and light chains in an antibody, distinguishing it from other domain-level analyses by focusing on their combinatorial interaction as a determinant of antigen-binding specificity.

30

Publications

2.7K

Citations

128

Authors

54

Institutions

Publications per year

2017–2026

6

Parents

Publications

30

"Diabodies": small bivalent and bispecific antibody fragments.

Philipp Holliger, Teresa Di Prospero, Greg Winter · Proceedings of the National Academy of Sciences · 1993 · 875 citations · Full text

, , +17

A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains

Woj M. Wojtowicz, Wei Wu, Ingemar André et al. · Cell · 2007 · 237 citations · Full text

, , +16

General strategy for the generation of human antibody variable domains with increased aggregation resistance

Kip Dudgeon, Romain Rouet, Iris Kokmeijer et al. · Proceedings of the National Academy of Sciences · 2012 · 191 citations · Full text

, , +17

The structural repertoire of the human V kappa domain.

Ian M. Tomlinson, J. P. Cox, Ermanno Gherardi et al. · The EMBO Journal · 1995 · 177 citations · Full text

, , +10

Structural Requirements for Biological Activity of the Ninth and Tenth FIII Domains of Human Fibronectin

Richard P. Grant, Claus Spitzfaden, Harri Altroff et al. · Journal of Biological Chemistry · 1997 · 139 citations · Full text

, , +17

1–5 of 30

Authors

128

  1. KA
    Kathleen Ahrens

    National Taiwan University, Taiwan

    2 publications · 65 citations

    2

    h-index

  2. KD
    Karen D. Moulton

    Bowdoin College, United States

    2 publications · 44 citations

    2

    h-index

  3. DC
    Donald C. Reason

    Children’s Institute, United States

    2 publications · 44 citations

    2

    h-index

  4. RJ
    Rainer Jaenicke

    University of Regensburg, Germany

    2 publications · 72 citations

    2

    h-index

  5. AH
    Alexander H. Lucas

    University of California San Diego, United States

    2 publications · 44 citations

    2

    h-index

1–5 of 128

Institutions

54

  1. University of Oxford

    Oxford, United Kingdom

    2 h-index

    5 publications

    695 citations

  2. Czech Academy of Sciences

    Prague, Czechia

    2 h-index

    3 publications

    111 citations

  3. University of Regensburg

    Regensburg, Germany

    2 h-index

    2 publications

    25 citations

  4. Institute of Physics

    Baku, Azerbaijan

    2 h-index

    2 publications

    116 citations

  5. Birkbeck, University of London

    London, United Kingdom

    2 h-index

    7 publications

    276 citations

  6. National Taiwan University

    Taipei, Taiwan

    2 h-index

    3 publications

    107 citations

  7. Academia Sinica

    Taipei, Taiwan

    2 h-index

    2 publications

    65 citations

  8. Science Oxford

    Oxford, United Kingdom

    2 h-index

    2 publications

    278 citations

1–8 of 54

Venues

  1. Protein Engineering Design and Selection

    PEDS · 2 publications · 94 citations

    2

    h-index

  2. mAbs

    1 publications · 17 citations

    2

    h-index

  3. Frontiers in Immunology

    2 publications · 124 citations

    2

    h-index

  4. PubMed

    Repository · 2 publications · 135 citations

    2

    h-index

  5. Czechoslovak Journal of Physics

    2 publications · 116 citations

    2

    h-index

1–5