Concepedia

Diversity (D) Segment Usage

Diversity (D) Segment Usage is a molecular genetic mechanism in immunoglobulin gene rearrangement that refers to the selective incorporation of diversity (D) gene segments into the variable region of immunoglobulin heavy chain genes during V(D)J recombination to increase antibody repertoire diversity.

14

Publications

2.3K

Citations

55

Authors

24

Institutions

Publications per year

2017–2026

0

Variants

D Segment Usage

Parents

Publications

14

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

F W Alt, D Baltimore · Proceedings of the National Academy of Sciences · 1982 · 760 citations · Full text

, , +14

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

Yoshikazu Kurosawa, Susumu Tonegawa · The Journal of Experimental Medicine · 1982 · 408 citations · Full text

, , +15

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

Simon Corbett, Ian M. Tomlinson, Erik L. L. Sonnhammer et al. · Journal of Molecular Biology · 1997 · 292 citations

, , +17

High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans

Ramy Arnaout, William Lee, Patrick Cahill et al. · PLoS ONE · 2011 · 211 citations · Full text

, , +17

The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire

Claude–Agnès Reynaud, Viviane Anquez, Jean–Claude Weill · European Journal of Immunology · 1991 · 107 citations

, , +15

1–5 of 14

Authors

55

  1. MF
    Melvyn F. Greaves

    The Honourable Society of Lincoln's Inn, United Kingdom

    1 publications · 55 citations

    1

    h-index

  2. ML
    Marie‐Paule Lefranc

    Centre National de la Recherche Scientifique, France

    1 publications · 62 citations

    1

    h-index

  3. BB
    Bryan Briney

    Scripps Research Institute, United States

    1 publications · 68 citations

    1

    h-index

  4. KR
    Klaus Rajewsky

    University of Cologne, Germany

    1 publications · 211 citations

    1

    h-index

  5. YK
    Yoshikazu Kurosawa

    Fujita Health University, Japan

    1 publications · 408 citations

    1

    h-index

1–5 of 55

Institutions

24

  1. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    4 publications

    2.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    5 publications

    310 citations

  3. Instituto Gulbenkian de Ciência

    Oeiras, Portugal

    1 h-index

    1 publications

    13 citations

  4. Whitehead Institute for Biomedical Research

    Cambridge, United States

    1 h-index

    2 publications

    1.5K citations

  5. The University of Osaka

    Osaka, Japan

    1 h-index

    3 publications

    234 citations

  6. University Hospital Ulm

    Ulm, Germany

    1 h-index

    3 publications

    192 citations

  7. Harvard University

    Cambridge, United States

    1 h-index

    2 publications

    422 citations

  8. Institute of Molecular and Clinical Ophthalmology Basel

    Basel, Switzerland

    1 h-index

    1 publications

    107 citations

1–8 of 24

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 871 citations

    3

    h-index

  2. European Journal of Immunology

    EJI · 2 publications · 120 citations

    2

    h-index

  3. The Journal of Experimental Medicine

    2 publications · 491 citations

    2

    h-index

  4. Journal of Biological Chemistry

    JBC · 1 publications · 40 citations

    1

    h-index

  5. The EMBO Journal

    1 publications · 55 citations

    1

    h-index

1–5