Concepedia

Disaggregation Mechanisms

Disaggregation Mechanisms is a molecular biological process that functions to disassemble misfolded protein aggregates into soluble polypeptides, distinguishing itself from other protein quality control mechanisms by its specific role in reversing aggregation through ATP-dependent chaperone systems.

288

Publications

18.7K

Citations

1.2K

Authors

406

Institutions

Publications per year

2017–2026

91

Parents

Publications

288

Protein disaggregation mediated by heat-shock protein Hspl04

Dawn A. Parsell, Anthony S. Kowal, Mike A. Singer et al. · Nature · 1994 · 870 citations

, , +11

Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB

Jimena Weibezahn, Peter Tessarz, Christian Schlieker et al. · Cell · 2004 · 469 citations · Full text

, , +17

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

Nadinath B. Nillegoda, Janine Kirstein, Anna Szlachcic et al. · Nature · 2015 · 380 citations · Full text

, , +10

Platelet aggregation

John O’Brien · Journal of Clinical Pathology · 1962 · 352 citations · Full text

, , +15

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

James Shorter · PLoS ONE · 2011 · 347 citations · Full text

, , +16

1–5 of 288

Authors

1.2K

  1. BB
    Bernd Bukau

    Heidelberg University, Germany

    21 publications · 3.7K citations

    20

    h-index

  2. AM
    Axel Mogk

    Heidelberg University, Germany

    17 publications · 2.4K citations

    16

    h-index

  3. JS
    James Shorter

    University of Pennsylvania, United States

    9 publications · 876 citations

    9

    h-index

  4. KL
    Krzysztof Liberek

    University of Gdańsk, Poland

    8 publications · 558 citations

    8

    h-index

  5. FT
    Francis Tsai

    Baylor College of Medicine, United States

    7 publications · 768 citations

    7

    h-index

1–5 of 1.2K

Institutions

406

  1. Heidelberg University

    Heidelberg, Germany

    19 h-index

    92 publications

    16K citations

  2. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    13 h-index

    55 publications

    9.4K citations

  3. German Cancer Research Center

    Heidelberg, Germany

    13 h-index

    48 publications

    7.9K citations

  4. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    40 publications

    3K citations

  5. National Institutes of Health

    Bethesda, United States

    9 h-index

    31 publications

    2.6K citations

  6. University of Gdańsk

    Gdansk, Poland

    7 h-index

    36 publications

    2.5K citations

  7. Baylor College of Medicine

    Houston, United States

    7 h-index

    28 publications

    2K citations

  8. University of Michigan

    Ann Arbor, United States

    5 h-index

    12 publications

    913 citations

1–8 of 406

Venues

  1. Journal of Biological Chemistry

    JBC · 20 publications · 1.9K citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 977 citations

    12

    h-index

  3. Scientific Reports

    7 publications · 174 citations

    7

    h-index

  4. The Journal of Cell Biology

    JCB · 5 publications · 552 citations

    5

    h-index

  5. PLoS ONE

    4 publications · 487 citations

    4

    h-index

1–5