Concepedia

Directed Molecular Evolution

Directed Molecular Evolution is a laboratory-based iterative process within protein engineering that involves the guided optimization of biomolecules through recurrent cycles of genetic diversification and selective enrichment to achieve enhanced or novel functional properties.

179

Publications

10.5K

Citations

857

Authors

323

Institutions

Publications per year

2017–2026

59

Variants

Laboratory Evolution

Parents

Publications

179

In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

Deniz Dalkara, Leah C. Byrne, R. R. Klimczak et al. · Science Translational Medicine · 2013 · 733 citations

, , +16

A system for the continuous directed evolution of biomolecules

Kevin M. Esvelt, Jacob C. Carlson, David R. Liu · Nature · 2011 · 726 citations · Full text

, , +7

A general strategy for the evolution of bond-forming enzymes using yeast display

Irwin Chen, Brent M. Dorr, David R. Liu · Proceedings of the National Academy of Sciences · 2011 · 590 citations · Full text

, , +17

Directed evolution of CRISPR-Cas9 to increase its specificity

Jungjoon K. Lee, Seokjoong Kim, Jin‐Soo Kim · Nature Communications · 2018 · 529 citations · Full text

, , +14

Microbial biotechnology: fundamentals of applied microbiology

Choice Reviews Online · 2008 · 258 citations

, , +9

1–5 of 179

Authors

857

  1. DR
    David R. Liu

    Harvard University, United States

    6 publications · 1.8K citations

    6

    h-index

  2. KD
    Kiryl D. Piatkevich

    McGovern Institute for Brain Research, United States

    5 publications · 188 citations

    5

    h-index

  3. MA
    Miguel Alcalde

    Instituto de Catálisis y Petroleoquímica, Spain

    5 publications · 231 citations

    5

    h-index

  4. US
    Ulrich Schwaneberg

    RWTH Aachen University, Germany

    5 publications · 304 citations

    5

    h-index

  5. RG
    Robert G. Whalen

    Institut Pasteur, France

    4 publications · 112 citations

    4

    h-index

1–5 of 857

Institutions

323

  1. Harvard University

    Cambridge, United States

    10 h-index

    39 publications

    7.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    12 publications

    3.6K citations

  3. Maxygen (United States)

    Redwood City, United States

    7 h-index

    23 publications

    589 citations

  4. Scripps Research Institute

    San Diego, United States

    6 h-index

    20 publications

    526 citations

  5. Instituto de Catálisis y Petroleoquímica

    Madrid, Spain

    5 h-index

    12 publications

    592 citations

  6. Constructor University

    Bremen, Germany

    5 h-index

    18 publications

    1.2K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    19 publications

    1K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    12 publications

    285 citations

1–8 of 323

Venues

  1. Protein Engineering Design and Selection

    PEDS · 14 publications · 404 citations

    12

    h-index

  2. Nature Communications

    8 publications · 1.1K citations

    8

    h-index

  3. Journal of Biological Chemistry

    JBC · 7 publications · 316 citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 1.3K citations

    6

    h-index

  5. ACS Synthetic Biology

    6 publications · 429 citations

    6

    h-index

1–5