In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

Deniz Dalkara, Leah C. Byrne, R. R. Klimczak, +5

Science Translational Medicine

Partial recovery of visual function in a blind patient after optogenetic therapy

José‐Alain Sahel, Élise Boulanger-Scemama, Chloé Pagot, +15

Nature Medicine

Partial RecoveryOphthalmologyVisual ImpairmentMedicineBlindsight +10

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

Najate Aït-Ali, Ram Fridlich, Géraldine Millet-Puel, +16

Cell

Molecular PhysiologyAerobic GlycolysisMedicinePhysiologyCellular Biochemistry +3

Inner Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous

Deniz Dalkara, Kathleen D. Kolstad, Natalia Caporale, +4

Molecular Therapy

Intravitreal Injection of AAV2 Transduces Macaque Inner Retina

Lu Yin, Kenneth P. Greenberg, Jennifer J. Hunter, +12

Investigative Ophthalmology & Visual Science

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

R. R. Klimczak, James T. Koerber, Deniz Dalkara, +2

PLoS ONE

Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

Émilie Macé, Romain Caplette, Olivier Marre, +9

Molecular Therapy

Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

James T. Koerber, R. R. Klimczak, Jae‐Hyung Jang, +3

Molecular Therapy

Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

Leah C. Byrne, Deniz Dalkara, Gabriel Luna, +5

Journal of Clinical Investigation

Ocular DiseaseViral-mediated RdcvfDifferent IsoformsRdcvfl ExpressionRetina +16

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

Abhishek Sengupta, Antoine Chaffiol, Émilie Macé, +10

EMBO Molecular Medicine