Concepedia

Directed Library Design

Directed Library Design is a protein engineering methodology that systematically generates focused variant libraries by incorporating prior structural and functional knowledge to target specific regions or residues for mutagenesis, thereby enhancing the efficiency of identifying thermostable mutants.

17

Publications

1.7K

Citations

111

Authors

32

Institutions

Publications per year

2017–2026

3

Parents

Publications

17

A transposase strategy for creating libraries of circularly permuted proteins

Manan Mehta, Shirley Liu, Jonathan J. Silberg · Nucleic Acids Research · 2012 · 1.1K citations · Full text

, , +16

Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death

Michael W. Robinson, Jean H. Overmeyer, Ashley Young et al. · Journal of Medicinal Chemistry · 2012 · 175 citations · Full text

, , +17

Directed evolution strategies for improved enzymatic performance

Edward G. Hibbert, Paul A. Dalby · Microbial Cell Factories · 2005 · 103 citations · Full text

, , +17

Error-Prone PCR and Effective Generation of Gene Variant Libraries for Directed Evolution

Janine N. Copp, Paulina Hanson‐Manful, David F. Ackerley et al. · Methods in molecular biology · 2014 · 72 citations

, , +15

Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

William J. Sanders, V. Nienaber, Claude G. Lerner et al. · Journal of Medicinal Chemistry · 2004 · 70 citations

, , +16

1–5 of 17

Authors

111

  1. CG
    Claude G. Lerner

    Abbott Fund, United States

    1 publications · 70 citations

    1

    h-index

  2. PA
    Paul A. Dalby

    University College London, United Kingdom

    1 publications · 103 citations

    1

    h-index

  3. DG
    David G. McKenna

    Abbott (United Kingdom), United Kingdom

    1 publications · 13 citations

    1

    h-index

  4. AJ
    Andy Jennings

    Takeda (United States), United States

    1 publications · 19 citations

    1

    h-index

  5. JW
    Jiangbo Wang

    Duke Medical Center, United States

    1 publications · 37 citations

    1

    h-index

1–5 of 111

Institutions

32

  1. University of British Columbia

    Vancouver, Canada

    2 h-index

    3 publications

    110 citations

  2. Rice University

    Houston, United States

    1 h-index

    3 publications

    3.2K citations

  3. Biochemical Society

    London, United Kingdom

    1 h-index

    2 publications

    206 citations

  4. Eli Lilly (United States)

    Indianapolis, United States

    1 h-index

    9 publications

    126 citations

  5. Irvine University

    Cerritos, United States

    1 h-index

    4 publications

    72 citations

  6. Southwestern Medical Center

    Lawton, United States

    1 h-index

    2 publications

    62 citations

  7. University of Toledo

    Toledo, United States

    1 h-index

    5 publications

    875 citations

  8. The University of Queensland

    Brisbane, Australia

    1 h-index

    4 publications

    68 citations

1–8 of 32

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 264 citations

    3

    h-index

  2. Biochemistry

    2 publications · 37 citations

    2

    h-index

  3. Methods in molecular biology

    Book series · 2 publications · 87 citations

    2

    h-index

  4. Microbial Cell Factories

    1 publications · 103 citations

    1

    h-index

  5. Protein Science

    PS · 1 publications · 12 citations

    1

    h-index

1–5