Concepedia

Differentiation Agents

Differentiation Agent is a type of antineoplastic drug that induces malignant cells to mature into more specialized, functionally normal cells by modulating gene expression and cellular development pathways, thereby inhibiting proliferation and promoting terminal differentiation instead of causing direct cytotoxicity.

188

Publications

7.8K

Citations

839

Authors

240

Institutions

Publications per year

2017–2026

14

Variants

Differentiation-inducing Agents

Parents

Publications

188

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

Victoria M. Richon, Yael Webb, R Merger et al. · Proceedings of the National Academy of Sciences · 1996 · 421 citations

, , +13

1α,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60)

Hirofumi Tanaka, E Abe, Chisato Miyaura et al. · Biochemical Journal · 1982 · 393 citations · Full text

, , +14

Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL‐60) by compounds which induce differentiation of murine leukemia cells

Steven Collins, Amos Bodner, R. C. Ting et al. · International Journal of Cancer · 1980 · 350 citations

, , +11

Induction of differentiation of the human histiocytic lymphoma cell line U-937 by 1 alpha,25-dihydroxycholecalciferol.

Inge Olsson, Urban Gullberg, Irene Ivhed et al. · PubMed · 1983 · 210 citations

, , +15

Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat.

Michael J. Wargovich, Chin‐Der Chen, Arnaldo Jimenez et al. · PubMed · 1996 · 184 citations

, , +16

1–5 of 188

Authors

839

  1. YH
    Yoshio Honma

    Saitama Cancer Center, Japan

    7 publications · 166 citations

    7

    h-index

  2. TK
    Takashi Kasukabe

    Saitama Cancer Center, Japan

    4 publications · 65 citations

    4

    h-index

  3. GP
    George P. Studzinski

    Rutgers, The State University of New Jersey, United States

    3 publications · 90 citations

    3

    h-index

  4. MK
    Masanori Kuroyanagi

    University of Shizuoka, Japan

    3 publications · 128 citations

    3

    h-index

  5. YK
    Yuzuru Kubohara

    Gunma University, Japan

    3 publications · 104 citations

    3

    h-index

1–5 of 839

Institutions

240

  1. Saitama Cancer Center

    Saitama, Japan

    8 h-index

    20 publications

    443 citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    7 h-index

    25 publications

    2.5K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    5 h-index

    14 publications

    4.4K citations

  4. National Cancer Institute

    Bethesda, United States

    5 h-index

    6 publications

    776 citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    7 publications

    129 citations

  6. University of Maryland, Baltimore

    Baltimore, United States

    4 h-index

    8 publications

    439 citations

  7. Cornell University

    Ithaca, United States

    4 h-index

    18 publications

    683 citations

  8. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    4 publications

    237 citations

1–8 of 240

Venues

  1. PubMed

    Repository · 55 publications · 2.4K citations

    27

    h-index

  2. Chemical and Pharmaceutical Bulletin

    4 publications · 170 citations

    4

    h-index

  3. Leukemia Research

    4 publications · 95 citations

    4

    h-index

  4. PLoS ONE

    4 publications · 140 citations

    4

    h-index

  5. International Journal of Cancer

    4 publications · 559 citations

    4

    h-index

1–5