Concepedia

Cyclin Degradation

Cyclin Degradation is a regulatory biochemical process in the cell cycle characterized by the targeted ubiquitin-mediated proteolysis of cyclin proteins, which ensures the unidirectional progression of cell cycle phases by inactivating cyclin-dependent kinase complexes.

927

Publications

82.9K

Citations

4.3K

Authors

1.1K

Institutions

Publications per year

2017–2026

139

Parents

Publications

927

Cyclin is degraded by the ubiquitin pathway

Michael Glotzer, Andrew W. Murray, Marc W. Kirschner · Nature · 1991 · 2.4K citations

, , +6

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

Michele Pagano, Sun W. Tam, Anne M. Theodoras et al. · Science · 1995 · 1.8K citations

, , +16

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

Tom Evans, Eric T. Rosenthal, Jim Youngblom et al. · Cell · 1983 · 1.5K citations

, , +16

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

Andrew W. Murray, Mark J. Solomon, Marc W. Kirschner · Nature · 1989 · 1.1K citations

, , +9

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

Massimo Loda, Barry Cukor, Sun W. Tam et al. · Nature Medicine · 1997 · 1K citations

, , +16

1–5 of 927

Authors

4.3K

  1. TH
    Tim Hunt

    University of Cambridge, United Kingdom

    16 publications · 3.8K citations

    15

    h-index

  2. MP
    Michele Pagano

    New York University, United States

    15 publications · 4.5K citations

    15

    h-index

  3. JR
    Joan Ruderman

    Harvard University, United States

    12 publications · 2.4K citations

    12

    h-index

  4. BE
    Bruce E. Clurman

    Fred Hutch Cancer Center, United States

    12 publications · 2.9K citations

    12

    h-index

  5. MW
    Marc W. Kirschner

    Harvard University, United States

    10 publications · 5.6K citations

    10

    h-index

1–5 of 4.3K

Institutions

1.1K

  1. Harvard University

    Cambridge, United States

    38 h-index

    174 publications

    40.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    33 h-index

    92 publications

    18.7K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    32 h-index

    151 publications

    12.5K citations

  4. New York University

    New York, United States

    17 h-index

    84 publications

    11.7K citations

  5. University of California, San Francisco

    San Francisco, United States

    17 h-index

    62 publications

    15.5K citations

  6. Kyushu University

    Fukuoka, Japan

    16 h-index

    84 publications

    6.6K citations

  7. National Institutes of Health

    Bethesda, United States

    15 h-index

    74 publications

    7.1K citations

  8. Chinese Academy of Sciences

    Beijing, China

    14 h-index

    100 publications

    4.5K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 73 publications · 6.3K citations

    46

    h-index

  2. Cell Cycle

    56 publications · 3.3K citations

    31

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 32 publications · 4.6K citations

    31

    h-index

  4. Molecular and Cellular Biology

    MCB · 42 publications · 2.9K citations

    30

    h-index

  5. The Journal of Cell Biology

    JCB · 31 publications · 5.2K citations

    30

    h-index

1–5