Concepedia

Cryptic Pocket Discovery

Cryptic Pocket Discovery is a computational or experimental method that identifies transient, hidden binding sites on proteins which are not evident in the protein’s static structure but can be stabilized for allosteric drug targeting.

47

Publications

3.3K

Citations

336

Authors

118

Institutions

Publications per year

2017–2026

38

Parents

Publications

47

Discovery of a Covalent Inhibitor of KRAS<sup>G12C</sup> (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 722 citations · Full text

, , +16

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites

Peter Cimermančič, Patrick Weinkam, T.J. Rettenmaier et al. · Journal of Molecular Biology · 2016 · 286 citations

, , +12

Understanding Cryptic Pocket Formation in Protein Targets by Enhanced Sampling Simulations

Vladimiras Oleinikovas, Giorgio Saladino, Benjamin P. Cossins et al. · Journal of the American Chemical Society · 2016 · 230 citations · Full text

, , +17

Predicting locations of cryptic pockets from single protein structures using the PocketMiner graph neural network

Artur Meller, Michael D. Ward, Jonathan Borowsky et al. · Nature Communications · 2023 · 176 citations · Full text

, , +13

Exploring the structural origins of cryptic sites on proteins

Dmitri Beglov, David Hall, Amanda Wakefield et al. · Proceedings of the National Academy of Sciences · 2018 · 144 citations · Full text

, , +15

1–5 of 47

Authors

336

  1. GR
    Gregory R. Bowman

    Washington University in St. Louis, United States

    9 publications · 592 citations

    9

    h-index

  2. JB
    Jonathan Borowsky

    Washington University in St. Louis, United States

    5 publications · 318 citations

    5

    h-index

  3. AM
    Artur Meller

    Washington University in St. Louis, United States

    5 publications · 371 citations

    5

    h-index

  4. MD
    Michael D. Ward

    Washington University in St. Louis, United States

    5 publications · 318 citations

    5

    h-index

  5. JM
    Jeffrey M. Lotthammer

    Washington University in St. Louis, United States

    3 publications · 220 citations

    3

    h-index

1–5 of 336

Institutions

118

  1. Washington University in St. Louis

    St Louis, United States

    9 h-index

    44 publications

    2.9K citations

  2. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    6 publications

    611 citations

  3. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    21 publications

    1.4K citations

  4. Institució Catalana de Recerca i Estudis Avançats

    Barcelona, Spain

    4 h-index

    4 publications

    190 citations

  5. Bioinformatics Institute

    Singapore, Singapore

    4 h-index

    16 publications

    372 citations

  6. Agency for Science, Technology and Research

    Singapore, Singapore

    4 h-index

    18 publications

    400 citations

  7. Institute of Structural and Molecular Biology

    London, United Kingdom

    3 h-index

    5 publications

    786 citations

  8. University College London

    London, United Kingdom

    3 h-index

    6 publications

    860 citations

1–8 of 118

Venues

  1. Journal of Chemical Theory and Computation

    JCTC · 5 publications · 284 citations

    5

    h-index

  2. Journal of Medicinal Chemistry

    5 publications · 851 citations

    4

    h-index

  3. Chemical Science

    4 publications · 283 citations

    4

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 45 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 240 citations

    3

    h-index

1–5