Concepedia

Covalent Binding Kinetics

Covalent Binding Kinetics is a quantitative framework that characterizes the rates of formation and breakdown of covalent bonds between a drug and its biological target, distinguishing it from non-covalent interaction models by explicitly accounting for irreversible or slowly reversible bond formation dynamics.

79

Publications

6.6K

Citations

313

Authors

94

Institutions

Publications per year

2017–2026

5

Parents

Publications

79

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

David J. Jollow, John R. Mitchell, Nicola Zampaglione et al. · Pharmacology · 2008 · 3.3K citations

, , +17

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

Phillip A. Schwartz, Petr Kuzmič, James Solowiej et al. · Proceedings of the National Academy of Sciences · 2013 · 281 citations · Full text

, , +16

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

Martin P. Zanni, Salomé von Greyerz, Benno Schnyder et al. · Journal of Clinical Investigation · 1998 · 239 citations · Full text

, , +17

Covalent binding and hemolytic activity of complement proteins.

S.K. Alex Law, N A Lichtenberg, R. P. Levine · Proceedings of the National Academy of Sciences · 1980 · 184 citations · Full text

, , +13

Reaction of aflatoxin B <sub>1</sub> <i>exo</i> -8,9-epoxide with DNA: Kinetic analysis of covalent binding and DNA-induced hydrolysis

William W. Johnson, F. Peter Guengerich · Proceedings of the National Academy of Sciences · 1997 · 126 citations · Full text

, , +17

1–5 of 79

Authors

313

  1. AE
    Ahmed E. Ahmed

    The University of Texas Medical Branch at Galveston, United States

    3 publications · 80 citations

    3

    h-index

  2. JR
    James R. Gillette

    National Heart Lung and Blood Institute, United States

    3 publications · 3.4K citations

    3

    h-index

  3. EP
    Edward P. Fisher

    National Energy Technology Laboratory, United States

    2 publications · 44 citations

    2

    h-index

  4. JD
    John DiGiovanni

    The University of Texas MD Anderson Cancer Center, United States

    2 publications · 44 citations

    2

    h-index

  5. SZ
    Sherif Z. Abdel‐Rahman

    The University of Texas Medical Branch at Galveston, United States

    2 publications · 66 citations

    2

    h-index

1–5 of 313

Institutions

94

  1. National Heart Lung and Blood Institute

    Bethesda, United States

    3 h-index

    7 publications

    13.3K citations

  2. The University of Texas Medical Branch at Galveston

    Galveston, United States

    3 h-index

    10 publications

    254 citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    5 publications

    140 citations

  4. The University of Texas at Austin

    Austin, United States

    2 h-index

    7 publications

    192 citations

  5. Lund University

    Lund, Sweden

    2 h-index

    11 publications

    137 citations

  6. Kumamoto University

    Kumamoto, Japan

    2 h-index

    9 publications

    301 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    6 publications

    168 citations

  8. University of Bern

    Bern, Switzerland

    1 h-index

    8 publications

    248 citations

1–8 of 94

Venues

  1. 6

    h-index

  2. PubMed

    Repository · 6 publications · 250 citations

    6

    h-index

  3. Drug Metabolism and Disposition

    6 publications · 318 citations

    6

    h-index

  4. Biochemical Pharmacology

    4 publications · 157 citations

    4

    h-index

  5. Biochemistry

    3 publications · 58 citations

    3

    h-index

1–5