Concepedia

Copper Overload Pathophysiology

Copper Overload Pathophysiology is a pathophysiological mechanism characterized by the progressive accumulation of copper in the liver and other organs due to impaired biliary copper excretion, primarily resulting from mutations in the ATP7B gene, leading to oxidative tissue damage and organ dysfunction.

172

Publications

8.8K

Citations

843

Authors

297

Institutions

Publications per year

2017–2026

48

Parents

Publications

172

h <i>CTR1</i> : A human gene for copper uptake identified by complementation in yeast

Bing Bing Zhou, Jane Gitschier · Proceedings of the National Academy of Sciences · 1997 · 563 citations · Full text

, , +15

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui, Arvin M. Gouw, Edward L. LaGory et al. · Nature Biotechnology · 2020 · 339 citations · Full text

, , +14

Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells

Saverio Tardito, Irene Bassanetti, Chiara Bignardi et al. · Journal of the American Chemical Society · 2011 · 317 citations

, , +15

Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model

Tasuku Hirayama, Genevieve C. Van de Bittner, Lawrence W. Gray et al. · Proceedings of the National Academy of Sciences · 2012 · 223 citations · Full text

, , +17

Increased cholesterol in plasma in a young man during experimental copper depletion

Leslie M. Klevay, Linda Inman, LuAnn K. Johnson et al. · Metabolism · 1984 · 201 citations

, , +10

1–5 of 172

Authors

843

  1. YJ
    Y. James Kang

    Sichuan University, China

    8 publications · 242 citations

    8

    h-index

  2. JT
    Jack T. Saari

    Grand Forks Human Nutrition Research Center, United States

    7 publications · 227 citations

    7

    h-index

  3. NA
    Nathalie Arnal

    Universidad Nacional de La Plata, Argentina

    6 publications · 154 citations

    6

    h-index

  4. CA
    Carlos A. Marra

    Biochemistry Research Institute of La Plata, Argentina

    5 publications · 127 citations

    5

    h-index

  5. MJ
    María J. T. de Alaniz

    Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

    5 publications · 127 citations

    5

    h-index

1–5 of 843

Institutions

297

  1. Grand Forks Human Nutrition Research Center

    Grand Forks, United States

    10 h-index

    19 publications

    2.1K citations

  2. Agricultural Research Service

    Washington, United States

    8 h-index

    17 publications

    2K citations

  3. University of Louisville

    Louisville, United States

    8 h-index

    28 publications

    1.1K citations

  4. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    7 h-index

    23 publications

    555 citations

  5. Instituto de Biotecnología y Biología Molecular

    La Plata, Argentina

    6 h-index

    20 publications

    511 citations

  6. Johns Hopkins University

    Baltimore, United States

    6 h-index

    42 publications

    3.7K citations

  7. Universidad Nacional de La Plata

    La Plata, Argentina

    6 h-index

    21 publications

    533 citations

  8. University of Liverpool

    Liverpool, United Kingdom

    5 h-index

    9 publications

    247 citations

1–8 of 297

Venues

  1. PubMed

    Repository · 13 publications · 549 citations

    12

    h-index

  2. Biological Trace Element Research

    7 publications · 141 citations

    7

    h-index

  3. Journal of Nutrition

    JN · 6 publications · 344 citations

    6

    h-index

  4. The Journal of Nutritional Biochemistry

    JNB · 6 publications · 203 citations

    6

    h-index

  5. BioMetals

    5 publications · 136 citations

    5

    h-index

1–5