Concepedia

Contact-dependent Suppression

Contact-Dependent Suppression is a regulatory mechanism employed by regulatory T cells that involves the direct requirement of cell-to-cell physical interaction to inhibit the activation and function of target immune cells, distinguishing it from soluble factor-mediated immunosuppressive processes.

286

Publications

27.9K

Citations

1.2K

Authors

372

Institutions

Publications per year

2017–2026

32

Parents

Publications

286

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Clare Baecher‐Allan, Julia A. Brown, Gordon J. Freeman et al. · The Journal of Immunology · 2001 · 1.8K citations · Full text

, , +17

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

Kazuhiko Nakamura, Atsushi Kitani, Warren Strober · The Journal of Experimental Medicine · 2001 · 1.6K citations · Full text

, , +17

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

Helmut Jonuleit, Edgar Schmitt, Michael Stassen et al. · The Journal of Experimental Medicine · 2001 · 1.2K citations · Full text

, , +17

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

Mindi Walker, Deborah J. Kasprowicz, Vivian H. Gersuk et al. · Journal of Clinical Investigation · 2003 · 1.2K citations · Full text

, , +17

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

David Gondek, Li‐Fan Lu, Sergio A. Quezada et al. · The Journal of Immunology · 2005 · 895 citations

, , +17

1–5 of 286

Authors

1.2K

  1. MZ
    Marek Zembala

    Jagiellonian University, Poland

    18 publications · 1.1K citations

    15

    h-index

  2. GL
    G L Asherson

    MRC Clinical Trials Unit at UCL, United Kingdom

    17 publications · 1K citations

    14

    h-index

  3. JW
    John W. Moorhead

    University of Colorado Denver, United States

    15 publications · 631 citations

    14

    h-index

  4. WP
    W Ptak

    Yale University, United States

    9 publications · 340 citations

    9

    h-index

  5. HN
    Henry N. Claman

    University of Colorado Denver, United States

    9 publications · 557 citations

    9

    h-index

1–5 of 1.2K

Institutions

372

  1. Harvard University

    Cambridge, United States

    17 h-index

    59 publications

    7.9K citations

  2. University of Colorado Denver

    Denver, United States

    13 h-index

    42 publications

    1.8K citations

  3. Yale University

    New Haven, United States

    10 h-index

    29 publications

    715 citations

  4. Brigham and Women's Hospital

    Boston, United States

    9 h-index

    26 publications

    7.7K citations

  5. National Institutes of Health

    Bethesda, United States

    9 h-index

    35 publications

    15.3K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    22 publications

    747 citations

  7. MRC Clinical Trials Unit at UCL

    London, United Kingdom

    8 h-index

    31 publications

    1.7K citations

  8. Inserm

    Paris, France

    7 h-index

    58 publications

    6.1K citations

1–8 of 372

Venues

  1. The Journal of Immunology

    JI · 72 publications · 9.3K citations

    39

    h-index

  2. The Journal of Experimental Medicine

    24 publications · 6.6K citations

    18

    h-index

  3. PubMed

    Repository · 29 publications · 905 citations

    16

    h-index

  4. European Journal of Immunology

    EJI · 15 publications · 1.3K citations

    15

    h-index

  5. PLoS ONE

    9 publications · 569 citations

    9

    h-index

1–5