Concepedia

Constitutive Knockout Models

Constitutive Knockout Model is a type of genetically engineered animal model in which a target gene is permanently inactivated throughout all tissues and developmental stages, distinguishing it from conditional or inducible knockout models by its universal and irreversible gene disruption.

29

Publications

1.1K

Citations

206

Authors

102

Institutions

Publications per year

2017–2026

14

Variants

Constitutive Knockout

Parents

Publications

29

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

Stefanie Giera, Yiyu Deng, Rong Luo et al. · Nature Communications · 2015 · 142 citations · Full text

, , +16

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Jiyun Peng, Yong Liu, Anthony D. Umpierre et al. · Molecular Brain · 2019 · 141 citations · Full text

, , +17

AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome

Suya Wang, Yifei Li, Yang Xu et al. · Circulation Research · 2020 · 122 citations · Full text

, , +15

Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice

A. Agostino · Human Molecular Genetics · 2003 · 90 citations · Full text

, , +14

Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice

Komuraiah Myakala, Sarah E. Motta, Heini Murer et al. · American Journal of Physiology-Renal Physiology · 2014 · 59 citations

, , +17

1–5 of 29

Authors

206

  1. PA
    Patricia A. Powers

    University of Wisconsin–Madison, United States

    1 publications · 30 citations

    1

    h-index

  2. LH
    Liang Huang

    Southwest University, China

    1 publications · 11 citations

    1

    h-index

  3. KM
    Kouhei Matsuda

    University of Toyama, Japan

    1 publications · 41 citations

    1

    h-index

  4. RF
    Raúl F. Pérez

    Nanomaterials and Nanotechnology Research Center, Spain

    1 publications · 16 citations

    1

    h-index

  5. MT
    Michael T. McManus

    University of California, San Francisco, United States

    1 publications · 18 citations

    1

    h-index

1–5 of 206

Institutions

102

  1. Washington University in St. Louis

    St Louis, United States

    2 h-index

    4 publications

    442 citations

  2. Nanchang University

    Nanchang, China

    2 h-index

    8 publications

    218 citations

  3. Inserm

    Paris, France

    2 h-index

    3 publications

    91 citations

  4. Boston Children's Hospital

    Boston, United States

    2 h-index

    16 publications

    2.2K citations

  5. Karolinska Institutet

    Stockholm, Sweden

    1 h-index

    2 publications

    110 citations

  6. Université de Montréal

    Montreal, Canada

    1 h-index

    5 publications

    75 citations

  7. Université Paris Cité

    Paris, France

    1 h-index

    2 publications

    32 citations

  8. Kyungpook National University Hospital

    Daegu, South Korea

    1 h-index

    4 publications

    116 citations

1–8 of 102

Venues

  1. Scientific Reports

    5 publications · 116 citations

    5

    h-index

  2. PLoS ONE

    3 publications · 64 citations

    3

    h-index

  3. Human Molecular Genetics

    2 publications · 129 citations

    2

    h-index

  4. genesis

    1 publications · 11 citations

    1

    h-index

  5. European Journal of Neuroscience

    EJN · 1 publications · 19 citations

    1

    h-index

1–5