Concepedia

Conformational Selection Engineering

Conformational Selection Engineering is a methodological framework in allosteric regulation engineering that directs the stabilization of pre-existing protein conformations through targeted perturbations, thereby exploiting the intrinsic dynamic equilibrium of macromolecular structures to achieve desired functional outcomes.

3

Publications

106

Citations

18

Authors

9

Institutions

Publications per year

2017–2026

1

Parents

Publications

3

Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

Jeffrey D. Munzar, Andy Ng, David Juncker · Nature Communications · 2018 · 54 citations · Full text

, , +17

VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody

Tomoyuki Igawa, Hiroyuki Tsunoda, Yasufumi Kikuchi et al. · Protein Engineering Design and Selection · 2010 · 36 citations · Full text

, , +16

Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs

Pei‐Ming Cheng, Tao Jia, Chong-Yang Li et al. · Nature Communications · 2024 · 19 citations · Full text

, , +17

Expanding the Conformational Selection Paradigm in Protein-Ligand Docking

Guray Kuzu, Özlem Keskin, Attila Gürsoy et al. · Methods in molecular biology · 2011 · 16 citations · Full text

, , +14

Efficiency Boost in Through Space Charge Transfer Emitters: Insights from Spiro Lateral Rocking Confinement

Ruihong Liu, Meng‐Tian Li, Yue‐Jian Yang et al. · Advanced Materials · 2024 · 14 citations

, , +14

1–5 of 3

Authors

18

  1. AG
    Attila Gürsoy

    Koç University, Türkiye

    1 publications · 16 citations

    1

    h-index

  2. TO
    Tsukasa Orita

    Kagoshima Prefectural College, Japan

    1 publications · 36 citations

    1

    h-index

  3. HT
    Hiroyuki Tsunoda

    Chugai Pharma (United States), United States

    1 publications · 36 citations

    1

    h-index

  4. DJ
    David Juncker

    McGill University, Canada

    1 publications · 54 citations

    1

    h-index

  5. JD
    Jeffrey D. Munzar

    McGill University, Canada

    1 publications · 54 citations

    1

    h-index

1–5 of 18

Institutions

9

  1. Center for Cancer Research

    Bethesda, United States

    1 h-index

    1 publications

    16 citations

  2. Mochida Pharmaceutical (Japan)

    Tokyo, Japan

    1 h-index

    11 publications

    396 citations

  3. McGill Genome Centre

    Montreal, Canada

    1 h-index

    1 publications

    54 citations

  4. McGill University and Génome Québec Innovation Centre

    Montreal, Canada

    1 h-index

    3 publications

    162 citations

  5. Tel Aviv University

    Tel Aviv, Israel

    1 h-index

    1 publications

    16 citations

  6. Chugai Pharma (United States)

    Berkeley Heights, United States

    1 h-index

    11 publications

    396 citations

  7. Koç University

    Istanbul, Türkiye

    1 h-index

    3 publications

    48 citations

  8. National Cancer Institute

    Bethesda, United States

    1 h-index

    1 publications

    16 citations

1–8 of 9

Venues

  1. Methods in molecular biology

    Book series · 1 publications · 16 citations

    1

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 1 publications · 36 citations

    1

    h-index

  3. Nature Communications

    1 publications · 54 citations

    1

    h-index

  4. Advanced Materials

    1 publications · 14 citations

1–4