Concepedia

Computational Protein Design

Computational Protein Design is a computational methodology that systematically generates novel amino acid sequences or protein structures with desired functions or properties by leveraging physics-based modeling, machine learning, or energy landscape theory within the framework of protein engineering.

356

Publications

31.6K

Citations

1.5K

Authors

419

Institutions

Publications per year

2017–2026

163

Parents

Publications

356

De novo design of protein structure and function with RFdiffusion

Joseph L. Watson, David Juergens, Nathaniel R. Bennett et al. · Nature · 2023 · 2K citations · Full text

, , +15

Robust deep learning–based protein sequence design using ProteinMPNN

Justas Dauparas, Ivan Anishchenko, Nathaniel R. Bennett et al. · Science · 2022 · 1.9K citations · Full text

, , +14

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Brian Kuhlman, Gautam Dantas, Gregory C. Ireton et al. · Science · 2003 · 1.7K citations

, , +15

De Novo Computational Design of Retro-Aldol Enzymes

Lin Jiang, Eric A. Althoff, Fernando R. Clemente et al. · Science · 2008 · 1.2K citations

, , +17

Unified rational protein engineering with sequence-based deep representation learning

Ethan C. Alley, Grigory Khimulya, Surojit Biswas et al. · Nature Methods · 2019 · 1.2K citations · Full text

, , +12

1–5 of 356

Authors

1.5K

  1. DB
    David Baker

    University of Washington, United States

    42 publications · 12K citations

    33

    h-index

  2. SL
    Stephen L. Mayo

    California Institute of Technology, United States

    17 publications · 1.2K citations

    16

    h-index

  3. TS
    Thomas Simonson

    Centre National de la Recherche Scientifique, France

    17 publications · 536 citations

    16

    h-index

  4. BK
    Brian Kuhlman

    University of North Carolina at Chapel Hill, United States

    12 publications · 3.4K citations

    12

    h-index

  5. BR
    Bruce R. Donald

    Duke University, United States

    12 publications · 497 citations

    12

    h-index

1–5 of 1.5K

Institutions

419

  1. University of Washington

    Seattle, United States

    39 h-index

    423 publications

    151.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    38 h-index

    102 publications

    46.7K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    109 publications

    3.8K citations

  4. École Polytechnique

    Palaiseau, France

    19 h-index

    80 publications

    2.5K citations

  5. California Institute of Technology

    Pasadena, United States

    17 h-index

    54 publications

    4.5K citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    14 h-index

    38 publications

    4K citations

  7. Harvard University

    Cambridge, United States

    13 h-index

    26 publications

    6.6K citations

  8. Stanford University

    Stanford, United States

    13 h-index

    37 publications

    3.6K citations

1–8 of 419

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 36 publications · 1.6K citations

    22

    h-index

  2. Proteins Structure Function and Bioinformatics

    23 publications · 1K citations

    21

    h-index

  3. Journal of Computational Chemistry

    20 publications · 932 citations

    17

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 2.2K citations

    16

    h-index

  5. PLoS Computational Biology

    18 publications · 932 citations

    16

    h-index

1–5