Concepedia

Complement-mediated Thrombosis

Complement-Mediated Thrombosis is a pathophysiological mechanism of thrombosis characterized by the aberrant activation of the complement system, which directly promotes coagulation cascade initiation, endothelial cell activation, and platelet aggregation, distinguishing it from thrombotic processes driven primarily by hemodynamic, platelet-intrinsic, or coagulation-factor-dominant pathways.

236

Publications

19.8K

Citations

1.4K

Authors

477

Institutions

Publications per year

2017–2026

91

Parents

Publications

236

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

Christophe Legendre, Christoph Licht, Petra Muus et al. · New England Journal of Medicine · 2013 · 1.6K citations · Full text

, , +17

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros, Alexandros Mitsios, Akrivi Chrysanthopoulou et al. · Journal of Clinical Investigation · 2020 · 798 citations · Full text

, , +17

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

SJ van Deventer, HR Buller, JW ten Cate et al. · Blood · 1990 · 783 citations · Full text

, , +16

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

P R Craddock, D. E. Hammerschmidt, James G. White et al. · Journal of Clinical Investigation · 1977 · 690 citations · Full text

, , +14

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

SJ van Deventer, HR Büller, JW ten Cate et al. · Blood · 1990 · 643 citations · Full text

, , +16

1–5 of 236

Authors

1.4K

  1. GR
    Giuseppe Remuzzi

    Mario Negri Institute for Pharmacological Research, Italy

    10 publications · 2.8K citations

    10

    h-index

  2. TE
    Tom Eirik Mollnes

    Oslo University Hospital, Norway

    10 publications · 379 citations

    10

    h-index

  3. JD
    John D. Lambris

    University of Pennsylvania, United States

    9 publications · 1.9K citations

    9

    h-index

  4. MN
    Marina Noris

    Mario Negri Institute for Pharmacological Research, Italy

    8 publications · 1.2K citations

    8

    h-index

  5. FT
    Francesco Tedesco

    University of Trieste, Italy

    5 publications · 676 citations

    5

    h-index

1–5 of 1.4K

Institutions

477

  1. University of Pennsylvania

    Philadelphia, United States

    11 h-index

    27 publications

    3.5K citations

  2. Nordland Hospital

    Bodø, Norway

    10 h-index

    21 publications

    659 citations

  3. Oslo University Hospital

    Oslo, Norway

    10 h-index

    26 publications

    1.2K citations

  4. University of Oslo

    Oslo, Norway

    9 h-index

    19 publications

    698 citations

  5. Mario Negri Institute for Pharmacological Research

    Milan, Italy

    9 h-index

    59 publications

    6.5K citations

  6. UiT The Arctic University of Norway

    Tromsø, Norway

    8 h-index

    42 publications

    1K citations

  7. University of Bern

    Bern, Switzerland

    7 h-index

    21 publications

    832 citations

  8. The Ohio State University

    Columbus, United States

    6 h-index

    19 publications

    818 citations

1–8 of 477

Venues

  1. Blood

    20 publications · 3.9K citations

    17

    h-index

  2. PubMed

    Repository · 10 publications · 500 citations

    10

    h-index

  3. The Journal of Immunology

    JI · 10 publications · 1.1K citations

    10

    h-index

  4. Thrombosis and Haemostasis

    8 publications · 524 citations

    8

    h-index

  5. Frontiers in Immunology

    7 publications · 203 citations

    7

    h-index

1–5