Concepedia

Complement-binding Antibodies

Complement-Binding Antibodies is a class of donor-specific antibodies that, upon binding to donor human leukocyte antigens, activates the complement cascade through the classical pathway, thereby mediating endothelial injury and contributing to transplant rejection.

591

Publications

33K

Citations

2.4K

Authors

664

Institutions

Publications per year

2017–2026

46

Variants

C1q-binding Antibodies

Parents

Publications

591

A plaque assay for all cells secreting Ig of a given type or class

E. GRONOWICZ, António Coutinho, Fritz Melchers · European Journal of Immunology · 1976 · 1K citations

, , +15

Fc receptor but not complement binding is important in antibody protection against HIV

Ann J. Hessell, Lars Hangartner, Meredith Hunter et al. · Nature · 2007 · 899 citations

, , +16

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival

Alexandre Loupy, Carmen Lefaucheur, Déwi Vernerey et al. · New England Journal of Medicine · 2013 · 833 citations · Full text

, , +17

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Christoph A. Diebolder, Frank J. Beurskens, Rob N. de Jong et al. · Science · 2014 · 784 citations

, , +14

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

Alun Davies, David L. Simmons, G Hale et al. · The Journal of Experimental Medicine · 1989 · 641 citations · Full text

, , +16

1–5 of 591

Authors

2.4K

  1. RP
    Ronald P. Taylor

    University of Virginia, United States

    17 publications · 1.4K citations

    14

    h-index

  2. FJ
    Frank J. Beurskens

    Genmab (Netherlands), Netherlands

    8 publications · 1.9K citations

    8

    h-index

  3. PW
    Paul W.H.I. Parren

    Genmab (Netherlands), Netherlands

    8 publications · 1.9K citations

    8

    h-index

  4. HW
    Herman Waldmann

    University of Oxford, United Kingdom

    7 publications · 1.3K citations

    7

    h-index

  5. JS
    Janine Schuurman

    Genmab (Netherlands), Netherlands

    7 publications · 1K citations

    7

    h-index

1–5 of 2.4K

Institutions

664

  1. Inserm

    Paris, France

    14 h-index

    38 publications

    8.2K citations

  2. University of Virginia

    Charlottesville, United States

    13 h-index

    84 publications

    4.9K citations

  3. New York University

    New York, United States

    12 h-index

    41 publications

    4K citations

  4. National Institutes of Health

    Bethesda, United States

    11 h-index

    40 publications

    2.3K citations

  5. Harvard University

    Cambridge, United States

    10 h-index

    32 publications

    1.5K citations

  6. Johns Hopkins University

    Baltimore, United States

    9 h-index

    26 publications

    1.1K citations

  7. Leiden University Medical Center

    Leiden, The Netherlands

    9 h-index

    17 publications

    2.9K citations

  8. Genmab (Netherlands)

    Utrecht, Netherlands

    8 h-index

    40 publications

    10.4K citations

1–8 of 664

Venues

  1. The Journal of Immunology

    JI · 51 publications · 2.7K citations

    30

    h-index

  2. PubMed

    Repository · 74 publications · 2.6K citations

    30

    h-index

  3. The Journal of Experimental Medicine

    25 publications · 2.9K citations

    20

    h-index

  4. Transplantation

    18 publications · 1.2K citations

    17

    h-index

  5. Experimental Biology and Medicine

    17 publications · 944 citations

    14

    h-index

1–5