Concepedia

Complement Therapeutics

Complement Therapeutics is a therapeutic strategy that belongs to the class of biomedical interventions designed to modulate the complement system, distinguished by its specific targeting of complement proteins or pathways to treat diseases characterized by complement dysregulation.

212

Publications

13.5K

Citations

1.6K

Authors

593

Institutions

Publications per year

2017–2026

99

Parents

Publications

212

The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, Neal S. Young, Jörg Schubert et al. · New England Journal of Medicine · 2006 · 1.3K citations · Full text

, , +17

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

Russell P. Rother, Scott A. Rollins, Christopher F. Mojcik et al. · Nature Biotechnology · 2007 · 764 citations

, , +13

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky, Neal S. Young, Elisabetta Antonioli et al. · Blood · 2007 · 653 citations

, , +11

C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration

Glenn J. Jaffe, Keith Westby, Karl G. Csaky et al. · Ophthalmology · 2020 · 446 citations · Full text

, , +16

Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study

Jong Wook Lee, Flore Sicre de Fontbrune, Lily Wong Lee Lee et al. · Blood · 2018 · 400 citations · Full text

, , +11

1–5 of 212

Authors

1.6K

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    15 publications · 994 citations

    14

    h-index

  2. AM
    Antonio M. Risitano

    University of Naples Federico II, Italy

    12 publications · 3.2K citations

    12

    h-index

  3. DR
    Daniel Ricklin

    University of Pennsylvania, United States

    10 publications · 563 citations

    10

    h-index

  4. HS
    Hubert Schrezenmeier

    Universität Ulm, Germany

    10 publications · 2.9K citations

    10

    h-index

  5. VM
    V. Michael Holers

    University of Colorado Denver, United States

    7 publications · 337 citations

    7

    h-index

1–5 of 1.6K

Institutions

593

  1. Alexion Pharmaceuticals (United States)

    Boston, United States

    17 h-index

    86 publications

    17.4K citations

  2. University of Pennsylvania

    Philadelphia, United States

    14 h-index

    47 publications

    2.9K citations

  3. Universität Ulm

    Ulm, Germany

    11 h-index

    20 publications

    1.4K citations

  4. Cleveland Clinic

    Cleveland, United States

    9 h-index

    11 publications

    2.6K citations

  5. University of Colorado Denver

    Denver, United States

    9 h-index

    17 publications

    804 citations

  6. University Hospital Ulm

    Ulm, Germany

    9 h-index

    17 publications

    2.4K citations

  7. University College London

    London, United Kingdom

    8 h-index

    22 publications

    1K citations

  8. Hôpital Saint-Louis

    Paris, France

    8 h-index

    15 publications

    3.4K citations

1–8 of 593

Venues

  1. Blood

    20 publications · 2.1K citations

    16

    h-index

  2. PubMed

    Repository · 6 publications · 180 citations

    6

    h-index

  3. Journal of Medicinal Chemistry

    6 publications · 149 citations

    6

    h-index

  4. Blood Advances

    5 publications · 253 citations

    5

    h-index

  5. The Journal of Immunology

    JI · 5 publications · 350 citations

    5

    h-index

1–5