Concepedia

Cofactor Binding Sites

Cofactor Binding Sites is a specialized region within an enzyme's three-dimensional structure that selectively accommodates and stabilizes non-protein cofactors essential for catalytic activity, distinguished from other binding sites by its specific molecular complementarity to prosthetic groups, coenzymes, or metal ions required for the enzyme’s functional integrity.

581

Publications

32.8K

Citations

2.5K

Authors

706

Institutions

Publications per year

2017–2026

75

Variants

Cofactor Binding Site

Parents

Publications

581

A multiplicity of CCAAT box-binding proteins

Arnulf Dorn, Jacques Bollekens, Adrian Staub et al. · Cell · 1987 · 746 citations

, , +9

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

N L Esmon, Whyte G. Owen, Charles T. Esmon · Journal of Biological Chemistry · 1982 · 707 citations · Full text

, , +14

Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis

Richard J. Heath, John R. Rubin, Debra R. Holland et al. · Journal of Biological Chemistry · 1999 · 547 citations · Full text

, , +15

Atomic Structure of Ferredoxin-NADP <sup>+</sup> Reductase: Prototype for a Structurally Novel Flavoenzyme Family

P. Andrew Karplus, Jon R. Herriott · Science · 1991 · 534 citations

, , +17

A Novel and Ubiquitous System for Membrane Targeting and Secretion of Cofactor-Containing Proteins

Joël H. Weiner, P T Bilous, Gillian Shaw et al. · Cell · 1998 · 465 citations · Full text

, , +15

1–5 of 581

Authors

2.5K

  1. DR
    Dennis R. Dean

    Virginia Tech, United States

    14 publications · 1.4K citations

    13

    h-index

  2. BM
    Brian M. Hoffman

    Northwestern University, United States

    11 publications · 878 citations

    11

    h-index

  3. LC
    Lance C. Seefeldt

    Utah State University, United States

    10 publications · 984 citations

    10

    h-index

  4. PJ
    Philip J. Fay

    University of Rochester, United States

    8 publications · 336 citations

    8

    h-index

  5. HW
    Hironao Wakabayashi

    University of Rochester, United States

    6 publications · 214 citations

    6

    h-index

1–5 of 2.5K

Institutions

706

  1. Virginia Tech

    Blacksburg, United States

    16 h-index

    62 publications

    6.2K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    72 publications

    3.3K citations

  3. University of Wisconsin–Madison

    Madison, United States

    14 h-index

    65 publications

    2.9K citations

  4. Utah State University

    Logan, United States

    14 h-index

    56 publications

    6.3K citations

  5. Northwestern University

    Evanston, United States

    14 h-index

    58 publications

    5.6K citations

  6. Scripps Research Institute

    San Diego, United States

    14 h-index

    50 publications

    3.6K citations

  7. University of California, Irvine

    Irvine, United States

    11 h-index

    41 publications

    2.8K citations

  8. University of California, San Francisco

    San Francisco, United States

    11 h-index

    40 publications

    2.7K citations

1–8 of 706

Venues

  1. Journal of Biological Chemistry

    JBC · 89 publications · 5.6K citations

    41

    h-index

  2. Biochemistry

    79 publications · 4.5K citations

    41

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 27 publications · 2.8K citations

    24

    h-index

  4. Journal of the American Chemical Society

    JACS · 23 publications · 1.6K citations

    20

    h-index

  5. Biochemical Journal

    BJ · 16 publications · 480 citations

    15

    h-index

1–5