Concepedia

Closed-state Inactivation

Closed-State Inactivation is a gating phenomenon in voltage-gated sodium channels wherein the channel transitions from a closed conformation to an inactivated state without prior opening, distinguishing it from inactivation pathways requiring channel activation.

106

Publications

8.4K

Citations

438

Authors

175

Institutions

Publications per year

2017–2026

13

Parents

Publications

106

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Toshimitsu Kawate, Jennifer Carlisle Michel, William T. Birdsong et al. · Nature · 2009 · 742 citations · Full text

, , +16

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Jian Payandeh, Tamer M. Gamal El-Din, Todd Scheuer et al. · Nature · 2012 · 488 citations

, , +16

Electrophysiological Properties of Mutant Na <sub>v</sub> 1.7 Sodium Channels in a Painful Inherited Neuropathy

Theodore Cummins, Sulayman D. Dib‐Hajj, Stephen G. Waxman · Journal of Neuroscience · 2004 · 399 citations · Full text

, , +17

Slow Closed-State Inactivation: A Novel Mechanism Underlying Ramp Currents in Cells Expressing the hNE/PN1 Sodium Channel

Theodore Cummins, James R. Howe, Stephen G. Waxman · Journal of Neuroscience · 1998 · 388 citations · Full text

, , +17

Nav1.3 Sodium Channels: Rapid Repriming and Slow Closed-State Inactivation Display Quantitative Differences after Expression in a Mammalian Cell Line and in Spinal Sensory Neurons

Theodore Cummins, Fabio Aglieco, Raimund I. Herzog et al. · Journal of Neuroscience · 2001 · 316 citations · Full text

, , +17

1–5 of 106

Authors

438

  1. TC
    Theodore Cummins

    Indiana University – Purdue University Indianapolis, United States

    6 publications · 1.6K citations

    6

    h-index

  2. SG
    Stephen G. Waxman

    Yale University, United States

    6 publications · 1.6K citations

    6

    h-index

  3. SD
    Sulayman D. Dib‐Hajj

    Yale University, United States

    5 publications · 1.2K citations

    5

    h-index

  4. WA
    William A. Catterall

    University of Washington, United States

    4 publications · 945 citations

    4

    h-index

  5. DF
    David Fedida

    University of British Columbia, Canada

    4 publications · 109 citations

    4

    h-index

1–5 of 438

Institutions

175

  1. Yale University

    New Haven, United States

    7 h-index

    25 publications

    4.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    6 publications

    1.5K citations

  3. Duke Medical Center

    Durham, United States

    4 h-index

    11 publications

    1.2K citations

  4. University of British Columbia

    Vancouver, Canada

    4 h-index

    12 publications

    335 citations

  5. University at Buffalo, State University of New York

    Buffalo, United States

    4 h-index

    7 publications

    119 citations

  6. Peking University

    Beijing, China

    4 h-index

    17 publications

    611 citations

  7. University of Washington

    Seattle, United States

    4 h-index

    16 publications

    4.2K citations

  8. University of Chicago

    Chicago, United States

    4 h-index

    7 publications

    732 citations

1–8 of 175

Venues

  1. The Journal of General Physiology

    JGP · 18 publications · 1.5K citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 762 citations

    9

    h-index

  3. The Journal of Physiology

    7 publications · 637 citations

    7

    h-index

  4. American Journal of Physiology-Cell Physiology

    5 publications · 102 citations

    5

    h-index

  5. Biophysical Journal

    5 publications · 187 citations

    5

    h-index

1–5