The crystal structure of a voltage-gated sodium channel

Jian Payandeh, Todd Scheuer, Ning Zheng, +1

Nature

Crystal StructureEngineeringApplied PhysicsCrystallographyCrystal Structure Design

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, +24

Nature

Reactive Nitrogen SpecieNitrosative StressCell DeathPlasma Membrane RuptureCellular Biochemistry +4

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

Jian Payandeh, Tamer M. Gamal El-Din, Todd Scheuer, +2

Nature

Crystal StructureVoltage-gated Sodium ChannelEngineeringPhysicsHyperpolarization (Biology) +5

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

Lin Tang, Tamer M. Gamal El-Din, Jian Payandeh, +5

Nature

Ca2+ SelectivityHyperpolarization (Biology)PhysiologyIon ChannelsElectrophysiology +2

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng, +32

Science

Voltage-gated SodiumMolecular BiologyMolecular PharmacologyIsoform SelectivityInhibitory Activity +16

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

Ji Sun, John R. Bankston, Jian Payandeh, +3

Nature

Crystal StructureCrystallographyCrystal Structure DesignChemistry

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

Daniel Lafkas, Amy L. Shelton, Cecilia Chiu, +20

Nature

Notch ControlInflammatory Lung DiseaseLung InflammationImmunologyPulmonary Physiology +11

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Nadia Martinez-Martin, Jessica Marcandalli, Christine Huang, +11

Cell

Molecular VirologyNeurovirologyUnbiased ScreenImmunologyViral Pathogenesis +6

Structural basis of α-scorpion toxin action on Na _v channels

Thomas Clairfeuille, Alexander Cloake, Daniel T. Infield, +12

Science

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Lionel Rougé, Nancy Chiang, Micah Steffek, +12

Science