NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, +24

Nature

Reactive Nitrogen SpecieNitrosative StressCell DeathPlasma Membrane RuptureCellular Biochemistry +4

Correcting mitochondrial fusion by manipulating mitofusin conformations

Antonietta Franco, Richard N. Kitsis, Julie Fleischer, +12

Nature

Membrane FusionMitochondrial FunctionBiochemistryProtein FoldingMedicine +5

IRF2 transcriptionally induces <i>GSDMD</i> expression for pyroptosis

Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, +16

Science Signaling

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Bettina L. Lee, Irma B. Stowe, Aaron Gupta, +7

The Journal of Experimental Medicine

Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Nobuhiko Kayagaki, Irma B. Stowe, Kamela Alegre, +26

Nature

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo

Opher S. Kornfeld, Nir Qvit, Bereketeab Haileselassie, +3

Scientific Reports

Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView

Takamasa Kudo, Ana M. Meireles, Reuben Moncada, +35

Nature Biotechnology

Tissue ImagingEngineeringMedical ImagingMicroscopyAdvanced Imaging +7

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Elisabet Bjånes, Reyna Garcia Sillas, Rina Matsuda, +18

PLoS Pathogens

ApoptosisImmunologyImmune RegulationCell DeathImmunologic Mechanism +22

Engineered Substrate‐Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics

Nir Qvit, Opher S. Kornfeld, Daria Mochly‐Rosen

Angewandte Chemie International Edition

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina Lee, +20

ApoptosisImmunologyCell DeathCell Death MechanismsCellular Physiology +16