Concepedia

Cleavage Specificity

Cleavage Specificity is a biochemical property that defines the precision with which a zinc finger nuclease recognizes and cleaves a particular DNA sequence site, distinguishing it from alternative genomic targets by minimizing off-site nuclease activity.

1.4K

Publications

95.3K

Citations

5.7K

Authors

1.3K

Institutions

Publications per year

2017–2026

153

Parents

Publications

1.4K

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

Gunnar von Heijne · European Journal of Biochemistry · 1983 · 2.3K citations · Full text

, , +17

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

Vikram Pattanayak, Steven Lin, John P. Guilinger et al. · Nature Biotechnology · 2013 · 1.5K citations · Full text

, , +6

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

Vipula K. Shukla, Yannick Doyon, Jeffrey C. Miller et al. · Nature · 2009 · 950 citations

, , +13

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

Eiko Ohuchi, Kazushi Imai, Yutaka Fujii et al. · Journal of Biological Chemistry · 1997 · 936 citations · Full text

, , +13

Separation and characterization of two extracelluar H<sub>2</sub>O<sub>2</sub>‐dependent oxidases from ligninolytic cultures of <i>Phanerochaete chrysosporium</i>

Masaaki Kuwahara, Jeffrey K. Glenn, Meredith A. Morgan et al. · FEBS Letters · 1984 · 794 citations · Full text

, , +14

1–5 of 1.4K

Authors

5.7K

  1. LH
    Lars Hellman

    Uppsala University, Sweden

    18 publications · 825 citations

    16

    h-index

  2. MT
    Michael Thorpe

    Uppsala University, Sweden

    12 publications · 449 citations

    12

    h-index

  3. IG
    I. Goldberg

    Harvard University, United States

    11 publications · 334 citations

    11

    h-index

  4. SM
    Sidney M. Hecht

    University of Virginia, United States

    11 publications · 765 citations

    11

    h-index

  5. PB
    Peter B. Dervan

    California Institute of Technology, United States

    11 publications · 1.7K citations

    11

    h-index

1–5 of 5.7K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    30 h-index

    128 publications

    22.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    30 h-index

    174 publications

    9.3K citations

  3. National Institutes of Health

    Bethesda, United States

    20 h-index

    84 publications

    7.2K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    20 h-index

    64 publications

    16.1K citations

  5. Washington University in St. Louis

    St Louis, United States

    17 h-index

    64 publications

    4.5K citations

  6. University of Pennsylvania

    Philadelphia, United States

    17 h-index

    50 publications

    4.4K citations

  7. Uppsala University

    Uppsala, Sweden

    17 h-index

    72 publications

    3.1K citations

  8. University of British Columbia

    Vancouver, Canada

    16 h-index

    58 publications

    6K citations

1–8 of 1.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 190 publications · 15.9K citations

    72

    h-index

  2. Nucleic Acids Research

    136 publications · 9.1K citations

    48

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 56 publications · 5.6K citations

    44

    h-index

  4. Biochemistry

    85 publications · 4.4K citations

    39

    h-index

  5. Journal of Virology

    JVI · 55 publications · 4.2K citations

    37

    h-index

1–5