Concepedia

Checkpoint Pathway Modulation

Checkpoint Pathway Modulation is a biological regulatory mechanism within the immune system that specifically fine-tunes inhibitory and stimulatory signals to maintain immune tolerance and prevent autoimmunity by selectively altering the activity of immune checkpoint molecules.

47

Publications

3.5K

Citations

406

Authors

139

Institutions

Publications per year

2017–2026

28

Parents

Publications

47

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

Patrick Steigemann, Claudia Wurzenberger, Michael H. A. Schmitz et al. · Cell · 2009 · 606 citations · Full text

, , +11

Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens

Efthymia Papalexi, Eleni P. Mimitou, Andrew Butler et al. · Nature Genetics · 2021 · 251 citations · Full text

, , +14

Specific checkpoints regulate plant cell cycle progression in response to oxidative stress

Jean‐Philippe Reichheld, Teva Vernoux, Filip Lardon et al. · The Plant Journal · 1999 · 243 citations · Full text

, , +17

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

Yuichi Hirose, Mitchel S. Berger, Russell O. Pieper · PubMed · 2001 · 236 citations

, , +17

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

Gil Ju Seo, Aerin Yang, Brandon Tan et al. · Cell Reports · 2015 · 208 citations · Full text

, , +17

1–5 of 47

Authors

406

  1. JJ
    Joseph J.�Y. Sung

    Chinese University of Hong Kong, Hong Kong SAR China

    2 publications · 191 citations

    2

    h-index

  2. RZ
    Robert Zeiser

    University Medical Center Freiburg, Germany

    2 publications · 43 citations

    2

    h-index

  3. RS
    Rong‐Guang Shao

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    2 publications · 44 citations

    2

    h-index

  4. KT
    Ka‐Fai To

    Chinese University of Hong Kong, Hong Kong SAR China

    2 publications · 191 citations

    2

    h-index

  5. SC
    Subhash C. Verma

    University of Nevada, Reno, United States

    1 publications · 19 citations

    1

    h-index

1–5 of 406

Institutions

139

  1. Nanyang Technological University

    Singapore, Singapore

    3 h-index

    8 publications

    887 citations

  2. National Institutes of Health

    Bethesda, United States

    2 h-index

    3 publications

    95 citations

  3. Capital Medical University

    Beijing, China

    2 h-index

    2 publications

    79 citations

  4. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    2 h-index

    41 publications

    3.1K citations

  5. Air Force Medical University

    Xi'an, China

    2 h-index

    28 publications

    4.3K citations

  6. University of Freiburg

    Freiburg im Breisgau, Germany

    2 h-index

    4 publications

    97 citations

  7. Ludwig-Maximilians-Universität München

    Munich, Germany

    2 h-index

    4 publications

    253 citations

  8. University Medical Center Freiburg

    Freiburg im Breisgau, Germany

    2 h-index

    4 publications

    97 citations

1–8 of 139

Venues

  1. PubMed

    Repository · 3 publications · 280 citations

    3

    h-index

  2. Oncogene

    3 publications · 176 citations

    3

    h-index

  3. Science Translational Medicine

    STM · 2 publications · 223 citations

    2

    h-index

  4. Cancer Immunology Immunotherapy

    2 publications · 72 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 48 citations

    2

    h-index

1–5