Concepedia

Chain Pairing Optimization

Chain Pairing Optimization is a computational and experimental framework in antibody specificity engineering that systematically enhances the correct pairing of heavy and light chains to maximize antigen-binding affinity and specificity through rational design or high-throughput screening.

7

Publications

322

Citations

79

Authors

14

Institutions

Publications per year

2017–2026

5

Parents

Publications

7

Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing

Per‐Johan Meijer, Peter S. Andersen, Margit Haahr Hansen et al. · Journal of Molecular Biology · 2006 · 125 citations

, , +16

A priori crystal structure prediction of native celluloses

Remco J. Viëtor, Karim Mazeau, Miles T. Lakin et al. · Biopolymers · 2000 · 65 citations

, , +17

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Starlynn Clarke, Biao Ma, Nathan D. Trinklein et al. · Frontiers in Immunology · 2019 · 43 citations · Full text

, , +17

Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies

Maximilian Bönisch, Carolin Sellmann, Daniel Maresch et al. · Protein Engineering Design and Selection · 2017 · 39 citations · Full text

, , +17

A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination

Matthias Birtel, Ralf-Holger Voss, Katharina Reinhard et al. · Cancer Research Communications · 2022 · 20 citations · Full text

, , +17

1–5 of 7

Authors

79

  1. JA
    J.W. Arndt

    Biogen (United States), United States

    1 publications · 17 citations

    1

    h-index

  2. AJ
    Allan Jensen

    Lundbeck (Denmark), Denmark

    1 publications · 125 citations

    1

    h-index

  3. MB
    Matthias Birtel

    University Medical Center of the Johannes Gutenberg University Mainz, Germany

    1 publications · 20 citations

    1

    h-index

  4. LD
    Laura Davison

    Cleveland Clinic, United States

    1 publications · 43 citations

    1

    h-index

  5. MS
    M Suchan

    BioNTech (Germany), Germany

    1 publications · 20 citations

    1

    h-index

1–5 of 79

Institutions

14

  1. Institut National de la Recherche Agronomique

    Rabat, Morocco

    1 h-index

    2 publications

    130 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    3 publications

    195 citations

  3. Biogen (United States)

    Cambridge, United States

    1 h-index

    8 publications

    136 citations

  4. Inserm

    Paris, France

    1 h-index

    2 publications

    86 citations

  5. Merck KGaA, Darmstadt (Germany)

    Darmstadt, Germany

    1 h-index

    4 publications

    156 citations

  6. Amgen (United States)

    Thousand Oaks, United States

    1 h-index

    10 publications

    130 citations

  7. University Medical Center of the Johannes Gutenberg University Mainz

    Mainz, Germany

    1 h-index

    7 publications

    140 citations

  8. BioNTech (Germany)

    Mainz, Germany

    1 h-index

    9 publications

    180 citations

1–8 of 14

Venues

  1. mAbs

    2 publications · 30 citations

    2

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 1 publications · 39 citations

    1

    h-index

  3. Cancer Research Communications

    CRC · 1 publications · 20 citations

    1

    h-index

  4. Frontiers in Immunology

    1 publications · 43 citations

    1

    h-index

  5. Biopolymers

    1 publications · 65 citations

    1

    h-index

1–5