Concepedia

Central Tolerance Failure

Central Tolerance Failure is a pathological mechanism in immunology whereby developing lymphocytes in the thymus fail to undergo deletion or inactivation of self-reactive clones, leading to the escape of autoreactive T cells into the periphery and subsequent breakdown of immune self-tolerance.

40

Publications

2.7K

Citations

303

Authors

151

Institutions

Publications per year

2017–2026

7

Parents

Publications

40

Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease

Eric P. Nagele, Min Han, Nimish K. Acharya et al. · PLoS ONE · 2013 · 307 citations · Full text

, , +17

A defect in central tolerance in NOD mice

Hidehiro Kishimoto, Jonathan Sprent · Nature Immunology · 2001 · 260 citations

, , +12

Immunological Unresponsiveness Induced by Cryptococcal Capsular Polysaccharide Assayed by the Hemolytic Plaque Technique

J W Murphy, George C. Cozad · Infection and Immunity · 1972 · 205 citations · Full text

, , +13

AIRE deficiency in thymus of 2 patients with Omenn syndrome

Patrizia Cavadini, William Vermi, Fabio Facchetti et al. · Journal of Clinical Investigation · 2005 · 152 citations

, , +17

AIRE deficiency in thymus of 2 patients with Omenn syndrome

Patrizia Cavadini, William Vermi, Fabio Facchetti et al. · Journal of Clinical Investigation · 2005 · 147 citations · Full text

, , +17

1–5 of 40

Authors

303

  1. AV
    Anna Villa

    Institute of Genetic and Biomedical Research, Italy

    3 publications · 313 citations

    3

    h-index

  2. LD
    Luigi D. Notarangelo

    National Institute of Allergy and Infectious Diseases, United States

    3 publications · 313 citations

    3

    h-index

  3. JD
    Jason DeVoss

    University of California, San Francisco, United States

    2 publications · 135 citations

    2

    h-index

  4. PC
    Patrizia Cavadini

    Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini", Italy

    2 publications · 299 citations

    2

    h-index

  5. RP
    Ricardo Pujol‐Borrell

    Universitat Autònoma de Barcelona, Spain

    2 publications · 136 citations

    2

    h-index

1–5 of 303

Institutions

151

  1. Inserm

    Paris, France

    5 h-index

    18 publications

    781 citations

  2. National Institutes of Health

    Bethesda, United States

    4 h-index

    6 publications

    205 citations

  3. University of Brescia

    Brescia, Italy

    3 h-index

    12 publications

    1.4K citations

  4. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    2 h-index

    6 publications

    336 citations

  5. Biogen (United States)

    Cambridge, United States

    2 h-index

    4 publications

    201 citations

  6. University of Toronto

    Toronto, Canada

    2 h-index

    2 publications

    71 citations

  7. Kyushu University

    Fukuoka, Japan

    2 h-index

    2 publications

    299 citations

  8. Charles University

    Prague, Czechia

    2 h-index

    2 publications

    187 citations

1–8 of 151

Venues

  1. The Journal of Immunology

    JI · 9 publications · 492 citations

    9

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 241 citations

    4

    h-index

  3. Journal of Clinical Investigation

    JCI · 4 publications · 398 citations

    4

    h-index

  4. Frontiers in Immunology

    2 publications · 31 citations

    2

    h-index

  5. The Journal of Experimental Medicine

    2 publications · 122 citations

    2

    h-index

1–5