Concepedia

Central Tolerance Establishment

Central Tolerance Establishment is a biological process in thymic development whereby self-reactive T cells are selectively eliminated or functionally inactivated during their maturation in the thymus to prevent autoimmunity.

60

Publications

4.1K

Citations

306

Authors

115

Institutions

Publications per year

2017–2026

7

Parents

Publications

60

CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance

Hirotsugu Kurobe, Cunlan Liu, Tomoo Ueno et al. · Immunity · 2006 · 303 citations · Full text

, , +13

Dendritic cells in the thymus contribute to T-regulatory cell induction

Anna I. Proietto, Serani van Dommelen, Penghui Zhou et al. · Proceedings of the National Academy of Sciences · 2008 · 302 citations · Full text

, , +17

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

Maarit Heino, Pärt Peterson, Jun Kudoh et al. · Biochemical and Biophysical Research Communications · 1999 · 289 citations

, , +16

A defect in central tolerance in NOD mice

Hidehiro Kishimoto, Jonathan Sprent · Nature Immunology · 2001 · 260 citations

, , +12

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

Tomoyoshi Yamano, Jelena Nedjic, Maria Hinterberger et al. · Immunity · 2015 · 251 citations · Full text

, , +13

1–5 of 60

Authors

306

  1. LK
    Ludger Klein

    Ludwig-Maximilians-Universität München, Germany

    5 publications · 727 citations

    5

    h-index

  2. BK
    Bruno Kyewski

    German Cancer Research Center, Germany

    5 publications · 540 citations

    5

    h-index

  3. LI
    Lauren I. R. Ehrlich

    The University of Texas at Austin, United States

    3 publications · 132 citations

    3

    h-index

  4. MH
    Maria Hinterberger

    Ludwig-Maximilians-Universität München, Germany

    3 publications · 552 citations

    3

    h-index

  5. YT
    Yousuke Takahama

    Tokushima University, Japan

    3 publications · 564 citations

    3

    h-index

1–5 of 306

Institutions

115

  1. German Cancer Research Center

    Heidelberg, Germany

    5 h-index

    13 publications

    1.8K citations

  2. Inserm

    Paris, France

    5 h-index

    6 publications

    214 citations

  3. Heidelberg University

    Heidelberg, Germany

    5 h-index

    13 publications

    1.8K citations

  4. Harvard University

    Cambridge, United States

    4 h-index

    12 publications

    1.2K citations

  5. Tokushima University

    Tokushima, Japan

    4 h-index

    21 publications

    4.4K citations

  6. The University of Texas at Austin

    Austin, United States

    3 h-index

    16 publications

    628 citations

  7. Centre d’Immunologie de Marseille-Luminy

    Marseille, France

    3 h-index

    4 publications

    93 citations

  8. Brigham and Women's Hospital

    Boston, United States

    3 h-index

    11 publications

    1.2K citations

1–8 of 115

Venues

  1. The Journal of Immunology

    JI · 8 publications · 404 citations

    8

    h-index

  2. The Journal of Experimental Medicine

    4 publications · 408 citations

    4

    h-index

  3. Immunity

    4 publications · 852 citations

    4

    h-index

  4. Journal of Autoimmunity

    4 publications · 109 citations

    4

    h-index

  5. Nature

    4 publications · 197 citations

    4

    h-index

1–5