Concepedia

Cdt1 Function In Replication Initiation

Cdt1 Function in Replication Initiation is a molecular mechanism in eukaryotic DNA replication that designates the regulated recruitment and loading of the MCM2–7 helicase complex onto replication origins during G1 phase, thereby licensing origins for subsequent initiation of DNA synthesis.

82

Publications

9K

Citations

352

Authors

143

Institutions

Publications per year

2017–2026

8

Parents

Publications

82

Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

James A. Wohlschlegel, Brian T. Dwyer, Suman Kumar Dhar et al. · Science · 2000 · 691 citations

, , +17

A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1

Jianping Jin, Emily E. Arias, Jing Chen et al. · Molecular Cell · 2006 · 640 citations · Full text

, , +10

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

Cécile Evrin, Pippa Clarke, Juergen Zech et al. · Proceedings of the National Academy of Sciences · 2009 · 551 citations

, , +17

The Cdt1 protein is required to license DNA for replication in fission yeast

Hideo Nishitani, Zoi Lygerou, Takeharu Nishimoto et al. · Nature · 2000 · 467 citations

, , +14

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4<sup>Cdt2</sup> ubiquitin ligase complex

Tarek Abbas, Uma Sivaprasad, Kenta Terai et al. · Genes & Development · 2008 · 368 citations · Full text

, , +17

1–5 of 82

Authors

352

  1. CS
    Christian Speck

    Imperial College London, United Kingdom

    7 publications · 1.1K citations

    7

    h-index

  2. JC
    Johannes C. Walter

    Harvard University, United States

    4 publications · 1.8K citations

    4

    h-index

  3. HL
    Huilin Li

    Van Andel Institute, United States

    4 publications · 881 citations

    4

    h-index

  4. CE
    Cécile Evrin

    Institut Pasteur, France

    4 publications · 666 citations

    4

    h-index

  5. BS
    Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    4 publications · 948 citations

    4

    h-index

1–5 of 352

Institutions

143

  1. Harvard University

    Cambridge, United States

    7 h-index

    20 publications

    8.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    14 publications

    1.7K citations

  3. Imperial College London

    London, United Kingdom

    5 h-index

    23 publications

    4.2K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    11 publications

    517 citations

  5. Wellcome Trust

    London, United Kingdom

    4 h-index

    8 publications

    814 citations

  6. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    4 h-index

    22 publications

    1K citations

  7. Tohoku University

    Sendai, Japan

    4 h-index

    13 publications

    676 citations

  8. University of Dundee

    Dundee, United Kingdom

    4 h-index

    8 publications

    814 citations

1–8 of 143

Venues

  1. Journal of Biological Chemistry

    JBC · 11 publications · 769 citations

    10

    h-index

  2. Nucleic Acids Research

    5 publications · 233 citations

    5

    h-index

  3. Cell Cycle

    5 publications · 282 citations

    5

    h-index

  4. Genes & Development

    5 publications · 1K citations

    5

    h-index

  5. The EMBO Journal

    5 publications · 659 citations

    5

    h-index

1–5