Concepedia

Cdr Grafting

CDR Grafting is a recombinant antibody engineering technique in which the complementarity-determining regions (CDRs) of a non-human antibody are transplanted into a human antibody framework to retain antigen specificity while reducing immunogenicity.

30

Publications

1.7K

Citations

223

Authors

59

Institutions

Publications per year

2017–2026

8

Variants

Complementarity-determining Region Grafting

Parents

Publications

30

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

Jared Adolf‐Bryfogle, Oleksandr Kalyuzhniy, Michael Kubitz et al. · PLoS Computational Biology · 2018 · 230 citations · Full text

, , +17

Humanization of a mouse monoclonal antibody by CDR–grafting: the importance of framework residues on loop conformation

Catherine Kettleborough, José W. Saldanha, Victoria J. Heath et al. · Protein Engineering Design and Selection · 1991 · 197 citations

, , +17

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Yannick D. Müller, Leonardo M. R. Ferreira, Émilie Ronin et al. · Frontiers in Immunology · 2021 · 98 citations · Full text

, , +17

In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification

Stefan Steidl, Olaf Ratsch, Bodo Brocks et al. · Molecular Immunology · 2008 · 95 citations

, , +16

Humanization of the anti-CEA T84.66 antibody based on crystal structure data

Paul J. Yazaki, Mark A. Sherman, J E Shively et al. · Protein Engineering Design and Selection · 2004 · 70 citations

, , +17

1–5 of 30

Authors

223

  1. LM
    Leonardo M. R. Ferreira

    University of California, San Francisco, United States

    2 publications · 109 citations

    2

    h-index

  2. NS
    Nikolaos Skartsis

    University of California, San Francisco, United States

    2 publications · 109 citations

    2

    h-index

  3. YZ
    Yu Zhou

    University of California, San Francisco, United States

    2 publications · 109 citations

    2

    h-index

  4. YD
    Yannick D. Müller

    University Hospital of Geneva, Switzerland

    2 publications · 109 citations

    2

    h-index

  5. AM
    Anupurna M. Kaul

    University of California, San Francisco, United States

    2 publications · 109 citations

    2

    h-index

1–5 of 223

Institutions

59

  1. Leiden University Medical Center

    Leiden, The Netherlands

    2 h-index

    4 publications

    218 citations

  2. Scripps Research Institute

    San Diego, United States

    2 h-index

    9 publications

    1.3K citations

  3. China Pharmaceutical University

    Nanjing, China

    2 h-index

    18 publications

    581 citations

  4. University of Zurich

    Zurich, Switzerland

    2 h-index

    9 publications

    544 citations

  5. University of California, San Francisco

    San Francisco, United States

    2 h-index

    28 publications

    1.5K citations

  6. San Francisco General Hospital

    San Francisco, United States

    2 h-index

    2 publications

    109 citations

  7. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    13 publications

    627 citations

  8. University of California, Irvine

    Irvine, United States

    1 h-index

    4 publications

    232 citations

1–8 of 59

Venues

  1. Protein Engineering Design and Selection

    PEDS · 7 publications · 522 citations

    7

    h-index

  2. Molecular Immunology

    2 publications · 148 citations

    2

    h-index

  3. Scientific Reports

    2 publications · 80 citations

    2

    h-index

  4. Frontiers in Immunology

    2 publications · 151 citations

    2

    h-index

  5. International Journal of Cancer

    1 publications · 58 citations

    1

    h-index

1–5