Concepedia

Capsid-directed Immunity

Capsid-Directed Immunity is an immune response category characterized by the targeting of viral capsid proteins by humoral and/or cellular immune mechanisms following gene therapy administration, distinguishing it from transgene-directed immunity by focusing on vector-encoded structural components rather than the therapeutic transgene product.

60

Publications

3.1K

Citations

394

Authors

129

Institutions

Publications per year

2017–2026

9

Parents

Publications

60

AAV-1–mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

Federico Mingozzi, J. J. M. Meulenberg, Daniel J. Hui et al. · Blood · 2009 · 284 citations · Full text

, , +13

Isolation of a capsid protein of bluetongue virus that induces a protective immune response in sheep

H. Huismans, N.T. Van der Walt, M. Cloete et al. · Virology · 1987 · 230 citations

, , +12

Immune Response to Recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity

Hanne Gahéry‐Ségard, Françoise Farace, Dominique Godfrin et al. · Journal of Virology · 1998 · 212 citations · Full text

, , +15

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

Luk H. Vandenberghe, Lili Wang, Suryanarayan Somanathan et al. · Nature Medicine · 2006 · 204 citations

, , +10

Epitope Type-Specific IgG Responses to Capsid Proteins VP1 and VP2 of Human Parvovirus B19

Mervi Söderlund, Colin Brown, Willy J. M. Spaan et al. · The Journal of Infectious Diseases · 1995 · 141 citations

, , +15

1–5 of 60

Authors

394

  1. KA
    Katherine A. High

    Children's Hospital of Philadelphia, United States

    4 publications · 468 citations

    4

    h-index

  2. GG
    Gerardo Guillén

    Centro de Ingeniería Genética y Biotecnología, Cuba

    3 publications · 147 citations

    3

    h-index

  3. LL
    Laura Lazo

    Centro de Ingeniería Genética y Biotecnología, Cuba

    3 publications · 147 citations

    3

    h-index

  4. LH
    Lisset Hermida

    Centro de Ingeniería Genética y Biotecnología, Cuba

    3 publications · 147 citations

    3

    h-index

  5. KM
    Kalyan Manna

    Indian Institute of Technology Kanpur, India

    2 publications · 41 citations

    2

    h-index

1–5 of 394

Institutions

129

  1. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    24 publications

    3.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    6 publications

    835 citations

  3. Children's Hospital of Philadelphia

    Philadelphia, United States

    4 h-index

    27 publications

    3.1K citations

  4. Inserm

    Paris, France

    3 h-index

    17 publications

    1.6K citations

  5. Centro de Ingeniería Genética y Biotecnología

    Havana, Cuba

    3 h-index

    26 publications

    1.4K citations

  6. Instituto de Medicina Tropical “Pedro Kourí”

    Havana, Cuba

    3 h-index

    6 publications

    305 citations

  7. Charles University

    Prague, Czechia

    2 h-index

    7 publications

    137 citations

  8. German Cancer Research Center

    Heidelberg, Germany

    2 h-index

    8 publications

    150 citations

1–8 of 129

Venues

  1. Vaccine

    13 publications · 401 citations

    13

    h-index

  2. Virology

    6 publications · 500 citations

    6

    h-index

  3. Journal of Virology

    JVI · 6 publications · 419 citations

    6

    h-index

  4. Virus Research

    3 publications · 82 citations

    3

    h-index

  5. 2

    h-index

1–5