BRCA2 Inactivation is a molecular event characterized by the loss or impairment of BRCA2 tumor suppressor gene function, resulting from genetic or epigenetic alterations that disrupt its role in DNA repair and genomic stability.
469
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2017–2026
116
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469
Identification of the breast cancer susceptibility gene BRCA2
Richard Wooster, Graham R. Bignell, Jonathan Lancaster et al. · Nature · 1995 · 3.7K citations
Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia
Niall G. Howlett, Toshiyasu Taniguchi, Susan B. Olson et al. · Science · 2002 · 1.1K citations
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
Helen Davies, Dominik Głodzik, Sandro Morganella et al. · Nature Medicine · 2017 · 1.1K citations · Full text
Life Sciences, Genetics, Oncology +14
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai, Elizabeth M. Swisher, Beth Y. Karlan et al. · Nature · 2008 · 1.1K citations · Full text
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Shyam K. Sharan, Masami Morimatsu, Urs Albrecht et al. · Nature · 1997 · 1.1K citations · Full text
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1–5 of 3.5K
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943
University of Cambridge
Cambridge, United Kingdom
24 h-index
115 publications
25.2K citations
University of Toronto
Toronto, Canada
22 h-index
84 publications
12.8K citations
Women's College Hospital
Toronto, Canada
18 h-index
57 publications
14.9K citations
Dana-Farber Cancer Institute
Boston, United States
18 h-index
57 publications
18.1K citations
Cancer Research UK
London, United Kingdom
17 h-index
58 publications
9.6K citations
Institute of Cancer Research
London, United Kingdom
17 h-index
118 publications
99.5K citations
Cancer Genetics (United States)
Rutherford, United States
16 h-index
43 publications
3.6K citations
Memorial Sloan Kettering Cancer Center
New York, United States
16 h-index
112 publications
26.8K citations
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- Breast Cancer Research and Treatment
34 publications · 1.9K citations
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- Oncogene
23 publications · 1.9K citations
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- Nature Genetics
13 publications · 6.3K citations
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- PubMed
Repository · 13 publications · 694 citations
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- British Journal of Cancer
BJC · 12 publications · 1.1K citations
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