Concepedia

Brca1 Inactivation

BRCA1 Inactivation is a tumor suppressor gene inactivation event characterized by the loss or disruption of BRCA1 function, thereby conferring increased susceptibility to genomic instability and carcinogenesis, particularly in hereditary breast and ovarian cancers.

1.5K

Publications

127.4K

Citations

10.7K

Authors

2.2K

Institutions

Publications per year

2017–2026

342

Parents

Publications

1.5K

Risks of cancer in BRCA1-mutation carriers

Daniel Ford · The Lancet · 1994 · 1.9K citations

, , +12

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Andrew Tutt, Mark E. Robson, Judy E. Garber et al. · The Lancet · 2010 · 1.6K citations

, , +13

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

Douglas F. Easton, Deborah Ford, D. Timothy Bishop · PubMed · 1995 · 1.6K citations

, , +16

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, François Vaillant, Di Wu et al. · Nature Medicine · 2009 · 1.5K citations

, , +16

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

Manel Esteller · JNCI Journal of the National Cancer Institute · 2000 · 1.2K citations · Full text

, , +16

1–5 of 1.5K

Authors

10.7K

  1. SA
    Steven A. Narod

    University of Toronto, Canada

    52 publications · 6.3K citations

    36

    h-index

  2. JL
    Jan Lubiński

    Pomeranian Medical University, Poland

    31 publications · 3.7K citations

    27

    h-index

  3. CD
    Chu‐Xia Deng

    National Institutes of Health, United States

    30 publications · 4.5K citations

    24

    h-index

  4. JE
    Judy E. Garber

    Dana-Farber Cancer Institute, United States

    20 publications · 4.3K citations

    18

    h-index

  5. XX
    Xiaoling Xu

    National Institutes of Health, United States

    18 publications · 3.5K citations

    18

    h-index

1–5 of 10.7K

Institutions

2.2K

  1. Dana-Farber Cancer Institute

    Boston, United States

    43 h-index

    214 publications

    46.3K citations

  2. Harvard University

    Cambridge, United States

    40 h-index

    265 publications

    53.4K citations

  3. National Institutes of Health

    Bethesda, United States

    39 h-index

    227 publications

    35.4K citations

  4. University of Toronto

    Toronto, Canada

    39 h-index

    158 publications

    27.7K citations

  5. Cancer Genetics (United States)

    Rutherford, United States

    34 h-index

    159 publications

    13.9K citations

  6. National Cancer Institute

    Bethesda, United States

    33 h-index

    170 publications

    20.4K citations

  7. Memorial Sloan Kettering Cancer Center

    New York, United States

    32 h-index

    252 publications

    38.9K citations

  8. The University of Texas MD Anderson Cancer Center

    Houston, United States

    32 h-index

    163 publications

    12.1K citations

1–8 of 2.2K

Venues

  1. Oncogene

    78 publications · 7.4K citations

    51

    h-index

  2. Breast Cancer Research and Treatment

    115 publications · 5.7K citations

    43

    h-index

  3. PubMed

    Repository · 59 publications · 7.3K citations

    35

    h-index

  4. Gynecologic Oncology

    55 publications · 3.1K citations

    28

    h-index

  5. Cancer Research

    30 publications · 3.1K citations

    26

    h-index

1–5