Concepedia

Bioisosteric Optimization

Bioisosteric Optimization is a computational or medicinal chemistry strategy that, as a method, involves the systematic replacement of molecular fragments with bioisosteres to improve pharmacokinetic, pharmacodynamic, or physicochemical properties while maintaining the desired biological activity.

71

Publications

2.4K

Citations

569

Authors

145

Institutions

Publications per year

2017–2026

27

Parents

Publications

71

Antibacterial chalcones––bioisosteric replacement of the 4′-hydroxy group

Simon Feldbæk Nielsen, Thomas Boesen, Mogens Larsen et al. · Bioorganic & Medicinal Chemistry · 2004 · 182 citations

, , +12

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

, , +17

FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

Simon Kleeb, Lijuan Pang, Katharina Mayer et al. · Journal of Medicinal Chemistry · 2015 · 94 citations

, , +15

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Michael R. Barbachyn, Gary J. Cleek, Lester A. Dolak et al. · Journal of Medicinal Chemistry · 2002 · 90 citations

, , +14

1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones

Eduardo H. G. da Cruz, Caio M.B. Hussene, Gleiston G. Dias et al. · Bioorganic & Medicinal Chemistry · 2014 · 77 citations

, , +13

1–5 of 71

Authors

569

  1. AB
    Armin Buschauer

    University of Regensburg, Germany

    3 publications · 69 citations

    3

    h-index

  2. CO
    Cristian Ochoa‐Puentes

    Universidad Nacional de Colombia, Colombia

    2 publications · 41 citations

    2

    h-index

  3. JL
    Jing-Ya Li

    Shanghai Institute of Materia Medica, China

    3 publications · 51 citations

    2

    h-index

  4. QY
    Qi-Zhuang Ye

    University of Kansas, United States

    2 publications · 34 citations

    2

    h-index

  5. SB
    Stefanie Bauer

    University of Regensburg, Germany

    2 publications · 41 citations

    2

    h-index

1–5 of 569

Institutions

145

  1. Pfizer (United States)

    New York, United States

    3 h-index

    20 publications

    676 citations

  2. University of Regensburg

    Regensburg, Germany

    3 h-index

    18 publications

    404 citations

  3. University of Kansas

    Lawrence, United States

    3 h-index

    9 publications

    228 citations

  4. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    5 publications

    151 citations

  5. University of Basel

    Basel, Switzerland

    2 h-index

    22 publications

    2K citations

  6. Shanghai Institutes for Biological Sciences

    Shanghai, China

    2 h-index

    19 publications

    323 citations

  7. National Center for Drug Screening

    Shanghai, China

    2 h-index

    20 publications

    340 citations

  8. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    26 publications

    512 citations

1–8 of 145

Venues

  1. Journal of Medicinal Chemistry

    22 publications · 1.1K citations

    20

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    9 publications · 253 citations

    9

    h-index

  3. European Journal of Medicinal Chemistry

    6 publications · 165 citations

    7

    h-index

  4. Bioorganic & Medicinal Chemistry

    5 publications · 328 citations

    5

    h-index

  5. MedChemComm

    3 publications · 54 citations

    3

    h-index

1–5