Concepedia

Bioactivation Screening

Bioactivation Screening is a systematic methodological framework used in drug discovery and toxicology research to identify compounds that undergo metabolic transformation into reactive metabolites, thereby distinguishing potential bioactivation pathways that may lead to toxicity from those that do not.

47

Publications

2.3K

Citations

267

Authors

79

Institutions

Publications per year

2017–2026

11

Parents

Publications

47

Bioactivation as a Model for Drug Design Bioreductive Alkylation

Harold W. Moore · Science · 1977 · 433 citations

, , +5

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

R. Scott Obach, Amit S. Kalgutkar, John R. Soglia et al. · Chemical Research in Toxicology · 2008 · 213 citations

, , +17

Ah Receptor-Based Chemical Screening Bioassays: Application and Limitations for the Detection of Ah Receptor Agonists

Shawn D. Seidel · Toxicological Sciences · 2000 · 108 citations

, , +17

Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.

David Ross, Howard D. Beall, R D Traver et al. · PubMed · 1994 · 107 citations

, , +15

Thiazolidinedione Bioactivation:  A Comparison of the Bioactivation Potentials of Troglitazone, Rosiglitazone, and Pioglitazone Using Stable Isotope-Labeled Analogues and Liquid Chromatography Tandem Mass Spectrometry

Rubén Alvarez‐Sánchez, François Montavon, Thomas Härtung et al. · Chemical Research in Toxicology · 2006 · 91 citations

, , +15

1–5 of 47

Authors

267

  1. SJ
    S. Joshua Swamidass

    Washington University in St. Louis, United States

    3 publications · 60 citations

    3

    h-index

  2. AS
    Amit S. Kalgutkar

    Pfizer (United States), United States

    3 publications · 308 citations

    3

    h-index

  3. GS
    Gregory S. Walker

    Pfizer (United States), United States

    2 publications · 95 citations

    2

    h-index

  4. DA
    Dustyn A. Barnette

    University of Arkansas for Medical Sciences, United States

    2 publications · 40 citations

    2

    h-index

  5. ML
    Márcio Luís Andrade e Silva

    Universidade de Franca, Brazil

    2 publications · 69 citations

    2

    h-index

1–5 of 267

Institutions

79

  1. Pfizer (United States)

    New York, United States

    5 h-index

    30 publications

    2.1K citations

  2. Washington University in St. Louis

    St Louis, United States

    3 h-index

    10 publications

    200 citations

  3. University of Guelph

    Guelph, Canada

    2 h-index

    5 publications

    101 citations

  4. Universidade Estadual de Mato Grosso do Sul

    Dourados, Brazil

    2 h-index

    2 publications

    61 citations

  5. Universidade Nova de Lisboa

    Lisbon, Portugal

    2 h-index

    6 publications

    135 citations

  6. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    6 publications

    138 citations

  7. National University of Singapore

    Singapore, Singapore

    2 h-index

    11 publications

    440 citations

  8. GlaxoSmithKline (United States)

    Philadelphia, United States

    2 h-index

    33 publications

    568 citations

1–8 of 79

Venues

  1. Chemical Research in Toxicology

    8 publications · 544 citations

    8

    h-index

  2. Mutagenesis

    4 publications · 99 citations

    4

    h-index

  3. Toxicological Sciences

    3 publications · 149 citations

    2

    h-index

  4. PubMed

    Repository · 2 publications · 118 citations

    2

    h-index

  5. Journal of Medicinal Chemistry

    2 publications · 57 citations

    2

    h-index

1–5