Concepedia

Binding Pocket Accommodation

Binding Pocket Accommodation is a structural adaptation mechanism in molecular recognition whereby the three-dimensional cavity of a biological target selectively adjusts its conformational or physicochemical properties to sterically and energetically tolerate bioisosteric substitutions within the ligand-binding site.

13

Publications

732

Citations

90

Authors

29

Institutions

Publications per year

2017–2026

3

Parents

Publications

13

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in <i>Mycobacterium tuberculosis</i>

Vadim Molodtsov, Nathan T. Scharf, Maxwell Stefan et al. · Molecular Microbiology · 2016 · 114 citations · Full text

, , +15

Structural insights of metallo-beta-lactamase revealed an effective way of inhibition of enzyme by natural inhibitors

Bhavya Gangadharappa, R. Sharath, Prasanna D. Revanasiddappa et al. · Journal of Biomolecular Structure and Dynamics · 2019 · 107 citations

, , +17

Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9

Derek F. Ceccarelli, Ivan M. Blasutig, Marilyn Goudreault et al. · Journal of Biological Chemistry · 2007 · 99 citations · Full text

, , +17

Noncovalent Tailoring of the Binding Pocket of Self-Assembled Cages by Remote Bulky Ancillary Groups

Yu Fang, Takashi Murase, Sota Sato et al. · Journal of the American Chemical Society · 2012 · 70 citations

, , +16

Total Syntheses and Initial Evaluation of [Ψ[C(═S)NH]Tpg<sup>4</sup>]vancomycin, [Ψ[C(═NH)NH]Tpg<sup>4</sup>]vancomycin, [Ψ[CH<sub>2</sub>NH]Tpg<sup>4</sup>]vancomycin, and Their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics

Akinori Okano, Atsushi Nakayama, Kejia Wu et al. · Journal of the American Chemical Society · 2015 · 68 citations

, , +15

1–5 of 13

Authors

90

  1. AH
    A. Heine

    Philipps University of Marburg, Germany

    1 publications · 32 citations

    1

    h-index

  2. QW
    Qian Wang

    Fudan University, China

    1 publications · 30 citations

    1

    h-index

  3. LL
    Lu Lu

    Fudan University, China

    1 publications · 30 citations

    1

    h-index

  4. MV
    M. van Oostendorp

    Eindhoven University of Technology, Netherlands

    1 publications · 29 citations

    1

    h-index

  5. FS
    Frank Sicheri

    Lunenfeld-Tanenbaum Research Institute, Canada

    1 publications · 99 citations

    1

    h-index

1–5 of 90

Institutions

29

  1. Pennsylvania State University

    State College, United States

    2 h-index

    5 publications

    348 citations

  2. Shanghai Institutes for Biological Sciences

    Shanghai, China

    1 h-index

    1 publications

    30 citations

  3. M S Ramaiah University of Applied Sciences

    Bengaluru, India

    1 h-index

    1 publications

    107 citations

  4. Siddaganga Institute of Technology

    Tumakuru, India

    1 h-index

    3 publications

    321 citations

  5. Scripps Research Institute

    San Diego, United States

    1 h-index

    8 publications

    544 citations

  6. The University of Tokyo

    Tokyo, Japan

    1 h-index

    4 publications

    280 citations

  7. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    3 publications

    90 citations

  8. Center for Excellence in Molecular Cell Science

    Shanghai, China

    1 h-index

    1 publications

    30 citations

1–8 of 29

Venues

  1. Journal of the American Chemical Society

    JACS · 3 publications · 187 citations

    3

    h-index

  2. Protein Science

    PS · 1 publications · 40 citations

    1

    h-index

  3. FEBS Letters

    1 publications · 14 citations

    1

    h-index

  4. Journal of Biomolecular Structure and Dynamics

    1 publications · 107 citations

    1

    h-index

  5. Journal of Medicinal Chemistry

    1 publications · 25 citations

    1

    h-index

1–5