Akinori Okano

Peripheral modifications of [Ψ[CH ₂ NH]Tpg ⁴ ]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics

Akinori Okano, Nicholas A. Isley, Dale L. Boger · Proceedings of the National Academy of Sciences · 2017 · 199 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

A Redesigned Vancomycin Engineered for Dual <scp>d</scp> -Ala- <scp>d</scp> -Ala and <scp>d</scp> -Ala- <scp>d</scp> -Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

Jian Xie, Joshua G. Pierce, Robert C. James et al. · Journal of the American Chemical Society · 2011 · 137 citations

Life Sciences, Biomolecular Engineering, Microbiology +15

Total Synthesis of [Ψ[C(═S)NH]Tpg⁴]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg⁴]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual <scp>d</scp>-Ala-<scp>d</scp>-Ala and <scp>d</scp>-Ala-<scp>d</scp>-Lac Binding

Jian Xie, Akinori Okano, Joshua G. Pierce et al. · Journal of the American Chemical Society · 2011 · 131 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Redesign of Glycopeptide Antibiotics: Back to the Future

Robert C. James, Joshua G. Pierce, Akinori Okano et al. · ACS Chemical Biology · 2012 · 116 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Total Synthesis of [Ψ[C(═NH)NH]Tpg⁴]Vancomycin and its (4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual <scp>d</scp>-Ala-<scp>d</scp>-Ala and <scp>d</scp>-Ala-<scp>d</scp>-Lac Binding

Akinori Okano, Atsushi Nakayama, Alex W. Schammel et al. · Journal of the American Chemical Society · 2014 · 81 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +14