Akinori Okano

Peripheral modifications of [Ψ[CH ₂ NH]Tpg ⁴ ]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics

Akinori Okano, Nicholas A. Isley, Dale L. Boger · Proceedings of the National Academy of Sciences · 2017 · 196 citations · Full text

A Redesigned Vancomycin Engineered for Dual <scp>d</scp> -Ala- <scp>d</scp> -Ala and <scp>d</scp> -Ala- <scp>d</scp> -Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

Jian Xie, Joshua G. Pierce, Robert C. James et al. · Journal of the American Chemical Society · 2011 · 134 citations

Total Synthesis of [Ψ[C(═S)NH]Tpg⁴]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg⁴]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual <scp>d</scp>-Ala-<scp>d</scp>-Ala and <scp>d</scp>-Ala-<scp>d</scp>-Lac Binding

Jian Xie, Akinori Okano, Joshua G. Pierce et al. · Journal of the American Chemical Society · 2011 · 129 citations

Medicinal Chemistry, Diversity Oriented Synthesis, Derivatives +12

Redesign of Glycopeptide Antibiotics: Back to the Future

Robert C. James, Joshua G. Pierce, Akinori Okano et al. · ACS Chemical Biology · 2012 · 115 citations · Full text

Bioorganic Chemistry, Glycobiology, Antimicrobial Chemotherapy +18

Total Synthesis of [Ψ[C(═NH)NH]Tpg⁴]Vancomycin and its (4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual <scp>d</scp>-Ala-<scp>d</scp>-Ala and <scp>d</scp>-Ala-<scp>d</scp>-Lac Binding

Akinori Okano, Atsushi Nakayama, Alex W. Schammel et al. · Journal of the American Chemical Society · 2014 · 80 citations · Full text

Antimicrobial Chemotherapy, Pharmaceutical Chemistry, Drug Resistance +22