Concepedia

Bcl-w Function

Bcl-W Function is a pro-survival protein function within the Bcl-2 family that selectively regulates mitochondrial outer membrane permeabilization by inhibiting pro-apoptotic BAX and BAK activation to maintain cellular viability.

80

Publications

6.9K

Citations

518

Authors

150

Institutions

Publications per year

2017–2026

10

Parents

Publications

80

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Mai Nguyen, Richard Marcellus, Anne Roulston et al. · Proceedings of the National Academy of Sciences · 2007 · 652 citations · Full text

, , +17

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Stefan Glaser, Erinna F. Lee, Evelyn Trounson et al. · Genes & Development · 2012 · 418 citations · Full text

, , +17

Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant

Cristin G. Print, Kate L. Loveland, Leonie Gibson et al. · Proceedings of the National Academy of Sciences · 1998 · 331 citations

, , +17

bcl-w, a novel member of the bcl-2 family, promotes cell survival.

Leonie Gibson, Shaun P Holmgreen, David C.S. Huang et al. · PubMed · 1996 · 310 citations

, , +9

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

Marcela Franco, Pernilla Roswall, Eliane Cortez et al. · Blood · 2011 · 305 citations · Full text

, , +15

1–5 of 80

Authors

518

  1. AS
    Andreas Strasser

    Walter and Eliza Hall Institute of Medical Research, Australia

    7 publications · 993 citations

    7

    h-index

  2. JM
    Jerry M. Adams

    Walter and Eliza Hall Institute of Medical Research, Australia

    7 publications · 1K citations

    7

    h-index

  3. DC
    David C.S. Huang

    Walter and Eliza Hall Institute of Medical Research, Australia

    6 publications · 890 citations

    6

    h-index

  4. HU
    Hong‐Duck Um

    Korea Institute of Radiological and Medical Sciences, South Korea

    6 publications · 604 citations

    6

    h-index

  5. IH
    In Hwa Bae

    Korea Institute of Radiological and Medical Sciences, South Korea

    5 publications · 236 citations

    5

    h-index

1–5 of 518

Institutions

150

  1. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    16 h-index

    105 publications

    15.7K citations

  2. Korea Institute of Radiological and Medical Sciences

    Seoul, South Korea

    9 h-index

    37 publications

    2.8K citations

  3. The University of Melbourne

    Melbourne, Australia

    8 h-index

    42 publications

    5.9K citations

  4. The Royal Melbourne Hospital

    Melbourne, Australia

    5 h-index

    26 publications

    6.3K citations

  5. Cincinnati Children's Hospital Medical Center

    Cincinnati, United States

    4 h-index

    13 publications

    513 citations

  6. University of Turku

    Turku, Finland

    4 h-index

    10 publications

    642 citations

  7. Harvard University

    Cambridge, United States

    3 h-index

    7 publications

    314 citations

  8. Legacy Health

    Portland, United States

    3 h-index

    15 publications

    599 citations

1–8 of 150

Venues

  1. Cell Death and Differentiation

    CDD · 4 publications · 196 citations

    4

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 377 citations

    4

    h-index

  3. PLoS ONE

    4 publications · 188 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 1.2K citations

    3

    h-index

  5. Molecular Endocrinology

    3 publications · 221 citations

    3

    h-index

1–5